Further studies on the maturation of the estrogen negative feedback on gonadotropin release in the female rat.

Neuroendocrinology
S R OjedaS M McCANN

Abstract

To evaluate estrogen negative feedback in infantile female rats, 9-day-old rats were ovariectomized (OVX) and treated with different doses of estradiol benzoate (Eb, s.c. once daily for 2 days); plasma LH, FSH and estradiol (E2) levels were then determined by RIA. The responses of these rats were compared with those of 25-day-old rats subjected to the same experimental procedures. In intact sham-operated controls, plasma FSH was elevated on days 9--13 and low on days 25--29, whereas LH did not change significantly throughout the period studied. OVX at day 9 or 25 increased the levels of both hormones, with the response faster and larger in the older rats. Treatment with Eb was more effective in suppressing the post-castration rise in gonadotropin levels in 27-day-old than in 11-day-old rats. At day 27 plasma E2 was elevated to pre-castration values by as little as 10 ng of Eb, whereas at day 11 this dose produced plasma E2 titers even higher than pre-castration values. Plasma E2 titers were high at 9--13 days of age and low at days 25--29. OVX on day 9 decreased E2 2--4 days later to about 1/2 the initial concentration, whereas adrenalectomy (ADRX) or ADRX-OVX was followed by an almost complete disappearance of the steroid. Whe...Continue Reading

Citations

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