PMID: 3991592May 1, 1985Paper

Further studies on the mechanism of fat-free diet (FFD)--protection against indomethacin-induced intestinal ulcers in the rat

Proceedings of the Society for Experimental Biology and Medicine
S EvangelistaA Meli

Abstract

A fat-free diet (FFD) reduces bacterial flora when compared to a regular diet (RD) in rats. FFD reduces the degree and incidence of indomethacin-induced intestinal ulceration concomitantly with a reduction in bacterial flora overgrowth produced by the drug. Present and previous findings indicate that diminished deconjugation of indomethacin and reduction of intestinal flora overgrowth play a major role in the ulcer-preventing properties of FFD.

Citations

Mar 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·J J Turek, I A Schoenlein

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