Further studies on the mechanism of the mineralocorticoid action of licorice in humans

Journal of Endocrinological Investigation
D ArmaniniV Zampollo

Abstract

The pathogenesis of pseudohyperaldosteronism from licorice has been evaluated in 6 male volunteers taking daily 7 g of a commercial preparation of licorice for 7 days, corresponding to an intake of 500 mg/day of glycyrrhizic acid. Pseudohyperaldosteronism was evident during the treatment (increase of body weight, suppression of plasma renin activity and plasma aldosterone, reduction of serum potassium). The ratio (tetrahydrocortisol + allo tetrahydrocortisol)/tetrahydrocortisone in urine increased in 5 cases after 3 days of treatment, without an increase of plasma mineralocorticoid activity (PMA). In the 6th case the urinary ratio was unchanged and PMA increased from the pretreatment value. After 7 days of therapy the ratio remained high and PMA was not measurable in 3 cases, while in the other 3 cases the ratio returned to pretreatment and PMA was higher than pretreatment value. We conclude that the pseudohyperaldosteronism from licorice is initially related to decreased activity of 11 beta-hydroxysteroid-dehydrogenase and afterwards also a direct effect of licorice derivatives on mineralocorticoid receptors becomes evident in some cases. In other cases however the effect on the enzyme is prevailing probably due to individual ...Continue Reading

References

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Citations

Sep 8, 2011·European Journal of Endocrinology·Paal MethlieKristian Løvås
Sep 17, 2005·Kidney International·Lorenzo A Calò, Decio Armanini
Feb 8, 2008·Experimental Animals·Sunhee ShinYun-bae Kim
Dec 11, 2008·Phytotherapy Research : PTR·Donatella PellatiGiulio Bertoloni
Sep 25, 2014·British Journal of Clinical Pharmacology·Chiara Di LorenzoPatrizia Restani
Jun 3, 2016·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Chiara Sabbadin, Decio Armanini
Dec 8, 2004·Steroids·Decio ArmaniniMario Palermo
Nov 28, 2012·Therapeutic Advances in Endocrinology and Metabolism·Hesham R OmarEnrico M Camporesi
Oct 9, 1999·The New England Journal of Medicine·D ArmaniniM Palermo
Jun 3, 2010·Clinical Science·Piotr SobieszczykJoshua A Beckman
Nov 5, 2003·Journal of Endocrinological Investigation·D ArmaniniI Karbowiak
Aug 2, 2003·Critical Reviews in Clinical Laboratory Sciences·Decio ArmaniniAndrea Semplicini
Sep 12, 2019·Frontiers in Endocrinology·Chiara SabbadinDecio Armanini
Aug 6, 2019·Frontiers in Endocrinology·Chiara SabbadinDecio Armanini
Oct 17, 2019·Foods·Mikkel R DeutchMarcus Krüger
Jul 24, 2021·Expert Opinion on Drug Discovery·Hidayat HussainSyed Tasadaque Ali Shah

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