Further studies on the potential contribution of acetaldehyde accumulation and oxidative stress in rat mammary tissue in the alcohol drinking promotion of breast cancer

Journal of Applied Toxicology : JAT
S L FanelliG D Castro

Abstract

There is available evidence supporting a positive association between alcohol intake and risk of breast cancer. However, there is limited information regarding possible mechanisms for this effect. Past studies from our laboratory suggest that acetaldehyde accumulation in mammary tissue after alcohol intake may be of particular relevance and that cytosolic and microsomal in situ bioactivation of ethanol to acetaldehyde and free radicals and the resulting stimulation of oxidative stress could be a significant early event related to tumor promotion. In the present studies repetitive alcohol drinking for 28 days was found to produce significant decreases in the mammary tissue content of GSH and alpha tocopherol and in glutathione S-transferase or glutathione reductase activities. In contrast, glutathione peroxidase activity was slightly increased. Malondialdehyde determinations did not show the occurrence of lipid peroxidation while the xylenol orange procedure gave positive results. The mammary microsomal metabolism of ethanol to acetaldehyde was not induced after an acute dose of ethanol or acetone able to induce the activity of its liver counterpart. The cytosolic pathway of alcohol metabolism instead was significantly enhanced ...Continue Reading

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Citations

Jul 19, 2014·Ukrainskiĭ biokhimicheskiĭ zhurnal·K O Tokarchuk, O V Zaitseva
Jan 13, 2015·Women's Health·Ying LiuGraham A Colditz
May 1, 2016·Alcoholism, Clinical and Experimental Research·Kevin D ShieldJürgen Rehm
May 28, 2016·International Journal of Environmental Research and Public Health·Yue ZhouHua-Bin Li
Sep 14, 2017·Breast Cancer Research : BCR·Jun WangSusan E Hankinson
Oct 11, 2014·World Journal of Clinical Oncology·Gerardo Daniel Castro, José A Castro
Mar 31, 2012·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Helmut K SeitzCarlo La Vecchia
Jan 25, 2011·Human & Experimental Toxicology·Lara R ButhetGerardo D Castro
Jan 22, 2021·The Cancer Journal·Frederick M Howard, Olufunmilayo I Olopade

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