Further studies on the rat posterodorsal medial amygdala: dendritic spine density and effect of 8-OH-DPAT microinjection on male sexual behavior

Brain Research Bulletin
Juliana de CastilhosAlberto A Rasia-Filho

Abstract

The rat posterodorsal medial amygdala (MePD) is a component of the neural network that modulates male sexual behavior. Dendritic spines were counted in Golgi-impregnated bitufted and stellate neurons and from cells located in the medial and lateral MePD subregions. It was also studied the effect of 8-OH-DPAT, a 5-HT1A receptor agonist, microinjected into the MePD on male sexual behavior. There were no significant differences in the dendritic spine density obtained from multipolar bitufted and stellate neurons (n = 48 cells in each group; p > 0.05) or in the data from the medial or the lateral MePD (n = 48 neurons per region; p > 0.05). Rats were stereotaxically microinjected into the MePD with saline (0.2 microl, n = 6) or 8-OH-DPAT (0.1 and 1.0 microg/0.2 microl, n = 6 and 5, respectively). Behavioral recordings prior to surgery and "non-target" microinjections served as additional control data. 8-OH-DPAT 1.0 microg decreased the latencies to intromission and ejaculation, the postejaculatory refractory period and the mount frequency when compared to control pre-surgery data (p < 0.05). When compared among groups, 8-OH-DPAT 1.0 microg promoted the highest percentage reduction in the postejaculatory refractory period. Saline and...Continue Reading

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Citations

Nov 19, 2013·Pharmacology, Biochemistry, and Behavior·Eelke M S SnoerenRonald S Oosting
Oct 17, 2013·Pharmacology, Biochemistry, and Behavior·Elisabeth Y BijlsmaRonald S Oosting
Apr 20, 2012·Canadian Journal of Physiology and Pharmacology·Helinton NeckelAlberto A Rasia-Filho
Feb 5, 2013·Behavioural Brain Research·Virgínia Meneghini LazzariMárcia Giovenardi
Nov 2, 2014·The Journal of Sexual Medicine·Trynke R de Jong, Inga D Neumann
Aug 10, 2010·Neuroscience Letters·Janaína BruscoAlberto A Rasia-Filho
Oct 10, 2009·Brain Research·Juliana de CastilhosMatilde Achaval
Aug 22, 2007·Neuroscience Letters·Simone MarcuzzoAlberto A Rasia-Filho
Jun 3, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Carolina Böettge RosaAlberto A Rasia-Filho
Mar 30, 2010·Journal of Neuroscience Methods·Aline Dall'OglioAlberto A Rasia-Filho
Nov 5, 2016·The European Journal of Neuroscience·Mariana ZancanAlberto A Rasia-Filho
Oct 2, 2021·Clinical and Experimental Immunology·Luciano Stürmer de FragaVictorio Bambini-Junior

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