PMID: 13779189Feb 1, 1961

Further studies on the role of proteases in the allergic reaction

The Journal of Experimental Medicine
G UNGARS KOBRIN

Abstract

Protease activity was measured through the hydrolysis of synthetic amino acid esters in body fluids and tissues of guinea pigs, rats, mice, and humans. Significant in vitro activation was observed in serum and lung slices of sensitized guinea pigs on addition of the specific antigen. Increased proteolytic activity was also seen in reverse anaphylaxis. More marked activation occurred when guinea pig serum was treated with peptone and guinea pig or rat serum was treated with agar. Protease activation was demonstrated in specimens of human skin under the influence of a poison ivy extract or croton oil added in vitro. Urinary protease activity of guinea pigs increased significantly during the first hours of anaphylactic shock and very markedly in peptone shock. Peptone shock, elicited in mice pretreated with H. pertussis, was accompanied by a considerable increase in protease activity in the peritoneal fluid as compared with non-pretreated mice which were insensitive to peptone. Proteolytic activity resulting from the activation procedures was due to a number of proteases. The dominant substrate affinity and inhibition patterns suggest that serum and urine proteases are similar to but not identical with plasmin. Anaphylactic activa...Continue Reading

References

Sep 1, 1959·The Journal of Experimental Medicine·E P BENDITT, M ARASE

Citations

Jan 1, 1969·Naunyn-Schmiedebergs Archiv Für Pharmakologie·W Vogt, J Lyncker
Aug 1, 1997·Journal of the History of the Neurosciences·B Setlow
Nov 1, 1965·The Journal of Pharmacy and Pharmacology·M K Paasonen
Mar 1, 1965·Archives internationales de physiologie et de biochimie·M CîrsteaI Butculescu
Jan 1, 1967·Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie·W Vogt
Jun 1, 1964·Archives internationales de physiologie et de biochimie·M CîrsteaG Suhaciu
Feb 26, 1963·Annals of the New York Academy of Sciences·D LAGUNOFF, E P BENDITT
Apr 1, 1965·Klinische Wochenschrift·W RAAB, E KAISER

Related Concepts

Allergic Reaction
Peptide Hydrolases

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.