Further validation of LABORAS using various dopaminergic manipulations in mice including MPTP-induced nigro-striatal degeneration

Journal of Neuroscience Methods
Leann P QuinnDavid J Virley

Abstract

The automated behavioural apparatus, LABORAS (Laboratory Animal Behaviour Observation, Registration and Analysis System), has been further validated with respect to the ability of the system to detect behavioural impairments in mice, following various dopaminergic manipulations. Initially data were obtained from mice administered with amphetamine, haloperidol, SCH23390, apomorphine and L-DOPA, with the focus on locomotor and grooming activities. The data recorded by LABORAS on administration of these pharmacological tool compounds, is comparable with published findings using standard LMA systems and conventional observer methods. In addition the home cage behaviour of mice administered with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) using an acute dosing regimen was also investigated. In LABORAS, mice subjected to MPTP lesioning showed deficits in spontaneous motor activity at day 6-7 post-MPTP administration, over a 24 h test period, as compared to saline treated controls. The data captured and analysed using LABORAS, suggests that the automated system is able to detect both pharmacologically and lesion-induced changes in behaviour of mice, reliably and efficiently.

References

Mar 25, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·U Strömberg, T H Svensson
Oct 7, 1986·European Journal of Pharmacology·P K Sonsalla, R E Heikkila
Jan 1, 1994·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·A Fredriksson, T Archer
Feb 1, 1997·Pharmacology, Biochemistry, and Behavior·U SchroederB A Sabel
Oct 9, 1998·Journal of Neuroscience Methods·G RozasJ L Labandeira-García
May 4, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·V M SimónM A Aguilar
Mar 20, 2001·Behavioural Processes·H A. Van de WeerdL F.M. Van Zutphen
Oct 24, 2001·Brain : a Journal of Neurology·A BerardelliM Hallett

❮ Previous
Next ❯

Citations

May 1, 2012·Clinical and Experimental Pharmacology & Physiology·Taline V KhroyanXinmin Xie
Jun 17, 2014·Pharmacology, Biochemistry, and Behavior·Aslıhan SayinHayrunnisa Bolay
Mar 20, 2012·Pharmacology, Biochemistry, and Behavior·Vincent CastagnéDavid Virley
Nov 17, 2010·Pharmacology, Biochemistry, and Behavior·Nikola LangeAngelika Richter
Mar 17, 2011·Journal of Pharmacological and Toxicological Methods·James J LynchScott W Mittelstadt
Dec 15, 2010·Neurology Research International·Seham A Gad ElhakMohamed M Salama
Sep 22, 2010·Cephalalgia : an International Journal of Headache·Didem AkcaliHayrunnisa Bolay
Sep 28, 2017·Molecular Psychiatry·N NagarajanM R Capecchi
Sep 30, 2020·International Journal of Oral Science·Jun LiDi Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here