FUS-mediated regulation of alternative RNA processing in neurons: insights from global transcriptome analysis

Wiley Interdisciplinary Reviews. RNA
Akio MasudaKinji Ohno

Abstract

Fused in sarcoma (FUS) is an RNA-binding protein that is causally associated with oncogenesis and neurodegeneration. Recently, the role of FUS in neurodegeneration has been extensively studied, because mutations in FUS are associated with amyotrophic lateral sclerosis (ALS), and the FUS protein has been identified as a major component of intracellular inclusions in neurodegenerative disorders including ALS and frontotemporal lobar degeneration. FUS is a key molecule in transcriptional regulation and RNA processing including processes such as pre-messenger RNA (mRNA) splicing and polyadenylation. Interaction of FUS with various components of the transcription machinery, spliceosome, and the 3'-end processing machinery has been identified. Furthermore, recent advances in high-throughput transcriptomic profiling approaches have enabled us to determine the mechanisms of FUS-dependent RNA processing networks at a cellular level. These analyses have revealed that depletion of FUS in neuronal cells affects alternative splicing and alternative polyadenylation of thousands of mRNAs. Gene ontology analysis has suggested that FUS-modulated genes are implicated in neuronal functions and development. CLIP-seq of FUS has shown that FUS is fr...Continue Reading

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Citations

Aug 11, 2016·Trends in Genetics : TIG·Dror HollanderGil Ast
Mar 5, 2019·Alcoholism, Clinical and Experimental Research·Yihong ZhaoZhi-Liang Zheng
Apr 24, 2017·Human Genetics·Vittoria PagliariniClaudio Sette
Aug 27, 2021·Frontiers in Molecular Neuroscience·Clara TejidoLudo Van Den Bosch

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