Fusaric acid: a novel agent and mechanism to treat HNSCC

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Brendan C StackChristopher S Hollenbeak

Abstract

A new class of carboxylic acids has tumoricidal activity for head and neck squamous cell cancer (HNSCC). Fusaric acid (FA) can chelate divalent cations, especially zinc, and inactivate zinc finger proteins involved in DNA repair and protein synthesis. 2 squamous carcinoma lines were utilized for in vitro and in vivo portions of this study. Cell counting and flow cytometry were used to analyze cells in culture in treatment and control groups over 96 hours. HNSCC subcutaneous implants were created in treatment and control groups of BALB-c nude mice (N = 30). In vitro studies demonstrated significant changes in cell numbers and cell cycle. In vivo studies of daily intralesional therapy for 1 month also showed reduced onset of growth and overall growth compared to controls. FA appears to have a tumoristatic/tumoricidal effect on HNSCC. Further nude mice studies are needed to optimize dosing and administration regimens for FA in anticipation of clinical trials.

References

Sep 9, 1977·Biochemical and Biophysical Research Communications·J A Fernandez-Pol
Jul 24, 1998·CA: a Cancer Journal for Clinicians·J F Carew, J P Shah
Apr 14, 1999·CA: a Cancer Journal for Clinicians·D M ParkinJ Ferlay
Oct 3, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K A VossW P Norred
Jan 5, 2002·Bioscience, Biotechnology, and Biochemistry·S OgataH Taguchi
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Annamaria RapellaMaria Carla Bosco
Feb 6, 2003·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jul 23, 2003·Archives of Otolaryngology--head & Neck Surgery·Claudell CoxTheodoros N Teknos
Jan 21, 2004·Archives of Otolaryngology--head & Neck Surgery·J Trad WadsworthO John Semmes
Mar 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·J Trad WadsworthO John Semmes

❮ Previous
Next ❯

Citations

Jan 25, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Sannaningaiah DevarajaKempaiah Kemparaju
Jun 7, 2014·Drugs in R&D·Brendan C StackHoward P Hendrickson
Jul 29, 2011·International Journal of Cancer. Journal International Du Cancer·Zhong-Yin YangQin-Long Gu
Jul 9, 2016·Toxicon : Official Journal of the International Society on Toxinology·Naeem Sheik AbdulAnil A Chuturgoon
May 8, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Terisha GhaziAnil A Chuturgoon

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
Flow Cytometry

Software Mentioned

GraphPad Prism
Modfit LT

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.