Fusaric acid alters Akt and ampk signalling in c57bl/6 mice brain tissue

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Shanel DhaniAnil A Chuturgoon

Abstract

The brain is a highly metabolic organ and requires regulatory mechanisms to meet its high energy demand, with the PI3K/Akt and AMPK signalling pathways being central regulators of cellular energy and metabolism, also making them major targets for the development of neurometabolic disorders. Fusaric acid (FA), a toxin of fungal origin, was found to be a potent hypotensive agent in vivo and in clinical trials by altering brain neurochemistry thus demonstrating its neurological effects. Notably, FA is a putative mitochondrial toxin, however, the metabolic effects of FA in the brain remains unknown. Therefore, this study investigates the neurometabolic effects of FA via alterations to Akt and AMPK signalling pathways in C57BL/6 mice at acute (1 day) and prolonged exposure (10 days). Following 1 day exposure, FA augmented Akt signalling by increasing Akt S473 phosphorylation and the upstream regulators PI3K, mTOR and p70S6K. Activated Akt showed inhibition of GSK3 activity with the simultaneous activation of AMPK, p53 phosphorylation and reduced GLUT-1 and -4 receptor expressions, potentially suppressing neuronal glucose entry. However, after 10 days exposure, FA dampened PI3K/Akt and AMPK signalling, but increased the expression of...Continue Reading

Citations

Jul 12, 2020·Journal of Agricultural and Food Chemistry·Sheng-Li NiuJin-Long Tian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.