Fusarisolins A⁻E, Polyketides from the Marine-Derived Fungus Fusarium solani H918

Marine Drugs
Siwen NiuXian-Wen Yang

Abstract

Five new (fusarisolins A⁻E, 1 to 5) and three known (6 to 8) polyketides were isolated from the marine-derived fungus Fusariumsolani H918, along with six known phenolics (9 to 14). Their structures were established by comprehensive spectroscopic data analyses, methoxyphenylacetic acid (MPA) method, chemical conversion, and by comparison with data reported in the literature. Compounds 1 and 2 are the first two naturally occurring 21 carbons polyketides featuring a rare β- and γ-lactone unit, respectively. All isolates (1 to 14) were evaluated for their inhibitory effects against tea pathogenic fungus Pestalotiopsis theae and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase gene expression. Compound 8 showed potent antifungal activity with an ED50 value of 55 μM, while 1, 8, 13, and 14 significantly inhibited HMG-CoA synthase gene expression.

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Citations

Jun 6, 2019·Organic & Biomolecular Chemistry·Shao-Qiang FanXian-Wen Yang
Feb 12, 2021·Natural Product Reports·Anthony R CarrollMichèle R Prinsep
Jan 5, 2021·Russian Journal of Bioorganic Chemistry·A A BaranovaA P Tyurin
Mar 26, 2021·Natural Product Research·Ting ZhaoXu-Hua Nong

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Datasets Mentioned

BETA
KY978584
M
2017151

Methods Mentioned

BETA
NMR
PCR

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