fused regulates germline cyst mitosis and differentiation during Drosophila oogenesis

Mechanisms of Development
Karine Narbonne-ReveauAnne-Marie Pret

Abstract

The fused gene encodes a serine-threonine kinase that functions as a positive regulator of Hedgehog signal transduction in Drosophila embryogenesis, wing morphogenesis, and somatic cell development during oogenesis. Here, we have characterized the germline ovarian tumors present in adult ovaries of fused mutant females, a phenotype not observed upon deregulation of any other component of Hedgehog signaling. In the strongest fused mutant contexts, we found that tumorous ovarian follicles accumulate early spectrosome-containing germ cells corresponding to germline stem cells and/or early cystoblasts as evidenced by activated Dpp signal transduction and transcriptional repression of bag-of-marbles, encoding the cystoblast determination factor. These early germ cells are maintained far from their usual position in a specialized niche of somatic cells in the apical part of the germarium, which appears normal in size in fused mutant ovarioles. Therefore, these results indicate a novel function for fused in downregulation of Dpp signaling which is necessary for de-repression of bag-of-marbles and consequent cystoblast determination. The abnormal accumulation of these early germ cells seems to be due primarily to defects in differentia...Continue Reading

References

Jun 1, 1990·The Quarterly Review of Biology·R Slee, M Bownes
Dec 1, 1990·Genes & Development·D M McKearin, A C Spradling
Jan 1, 1988·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R C King, P D Storto
Jan 1, 1970·Zeitschrift für Zellforschung und mikroskopische Anatomie·C C Dapples, R C King
Aug 1, 1994·Mechanisms of Development·E BaeR N Nagoshi
Apr 1, 1996·Mechanisms of Development·E Sánchez-HerreroI Guerrero
Feb 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D McKearin
Jan 1, 1997·Annual Review of Genetics·M de CuevasA C Spradling
Jan 23, 1999·Current Opinion in Cell Biology·H Lin
Oct 13, 2000·Science·T Xie, A C Spradling
Jul 13, 2001·Current Biology : CB·L Jones
Nov 2, 2001·Nature·A SpradlingT Kai
Apr 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Toshie Kai, Allan Spradling
Sep 20, 1957·Science·R C KING, R G BURNETT
Sep 8, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Florence BesseAnne-Marie Pret
Jul 1, 1988·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Denise BussonClaudie Lamour-Isnard

❮ Previous
Next ❯

Citations

Feb 22, 2011·Protein & Cell·Steven Y Cheng, Ying E Zhang
Aug 7, 2010·Trends in Cell Biology·Rita TewariJuliet C Coates
Sep 9, 2017·Stem Cells International·Shiqin LiZezheng Pan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.