Fusion genes and prostate cancer. From discovery to prognosis and therapeutic perspectives

Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie
P BeuzebocVincent Molinie

Abstract

The identification of fusion genes provides new insights into the initial mechanisms of molecular events implicated in the prostate cancer tumorigenesis. The presence of TEMPRSS2-ETS fusion in up to half of all human prostate cancer makes it perhaps the most common genetic rearrangement in human epithelial tumors. Some data suggest that TMPRSS2-ERG fusion prostate cancers have a more aggressive phenotype, which may affect cancer progression and outcome in localized tumors treated with prostatectomy. This discovery should pave the way towards future targeted therapies.

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Citations

Aug 13, 2010·Current Opinion in Supportive and Palliative Care

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