Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression.

Molecular Cancer
Xu-Chao ZhangYi-long Wu

Abstract

The anaplastic lymphoma kinase (ALK) gene is frequently involved in translocations that lead to gene fusions in a variety of human malignancies, including lymphoma and lung cancer. Fusion partners of ALK include NPM, EML4, TPM3, ATIC, TFG, CARS, and CLTC. Characterization of ALK fusion patterns and their resulting clinicopathological profiles could be of great benefit in better understanding the biology of lung cancer. RACE-coupled PCR sequencing was used to assess ALK fusions in a cohort of 103 non-small cell lung carcinoma (NSCLC) patients. Within this cohort, the EML4-ALK fusion gene was identified in 12 tumors (11.6%). Further analysis revealed that EML4-ALK was present at a frequency of 16.13% (10/62) in patients with adenocarcinomas, 19.23% (10/52) in never-smokers, and 42.80% (9/21) in patients with adenocarcinomas lacking EGFR and KRAS mutations. The EML4-ALK fusion was associated with non-smokers (P = 0.03), younger age of onset (P = 0.03), and adenocarcinomas without EGFR/KRAS mutations (P = 0.04). A trend towards improved survival was observed for patients with the EML4-ALK fusion, although it was not statistically significant (P = 0.20). Concurrent deletion in EGFR exon 19 and fusion of EML4-ALK was identified for t...Continue Reading

References

Oct 8, 2003·Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology·Leonard Hwan Cheong TanEvelyn Siew Chuan Koay
Aug 8, 2006·Experimental Cell Research·Marc PollmannHans-Juergen Heidebrecht
Oct 26, 2006·Pediatric Surgery International·Y KinoshitaM Tsuneyoshi
Feb 6, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Florence ArmstrongChristian Touriol
Jan 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kentaro InamuraYuichi Ishikawa
Feb 5, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kazuya ShinmuraHaruhiko Sugimura
Mar 6, 2008·Neoplasia : an International Journal for Oncology Research·Sven PernerMark A Rubin
Jul 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jussi P KoivunenPasi A Jänne
Sep 12, 2008·International Journal of Cancer. Journal International Du Cancer·Shi-Xu JiangIsao Okayasu
Oct 17, 2008·Nature·Isabelle Janoueix-LeroseyOlivier Delattre
Oct 17, 2008·Nature·Yuyan ChenSeishi Ogawa
Oct 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kengo TakeuchiHiroyuki Mano
Dec 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Manabu SodaHiroyuki Mano
Jan 17, 2009·The American Journal of Pathology·Maria Paola MartelliBrunangelo Falini
Jan 27, 2009·Cancer·Daisy Wing-Sze WongUNKNOWN University of Hong Kong Lung Cancer Study Group
Feb 24, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kentaro InamuraYuichi Ishikawa
Apr 23, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kengo TakeuchiHiroyuki Mano
May 13, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carolyn D SeibBrent T Shoji
May 23, 2009·The Biochemical Journal·Ruth H PalmerBengt Hallberg
Aug 12, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leora Horn, William Pao
Aug 12, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alice T ShawA John Iafrate
Nov 26, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amod A SarnaikVernon K Sondak
Dec 17, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Benjamin SolomonD Ross Camidge

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Citations

Jan 18, 2013·Targeted Oncology·Francesca CasaluceCesare Gridelli
Jan 28, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Liang ChengShaobo Zhang
Jul 5, 2012·The Pharmacogenomics Journal·A SavonarolaF Silvestris
Apr 19, 2011·Seminars in Respiratory and Critical Care Medicine·Ping Yang
Jun 5, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Justin F GainorAlice T Shaw
Mar 1, 2012·PloS One·Lisandra WestRavi Salgia
Apr 6, 2011·Future Oncology·Liang ChengAntonio Lopez-Beltran
Jun 5, 2013·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Vladimira KoudelakovaMarian Hajduch
Feb 5, 2014·Future Oncology·Adam GorczyńskiWojciech Biernat
Jan 21, 2014·Journal of Cancer Research and Clinical Oncology·Jinghui WangZongde Zhang
May 6, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Blanka RobesovaDana Dvorakova
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Mark W RichardsRichard Bayliss
Mar 29, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Evgeny A MoskalevFlorian Haller
Apr 11, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K M KerrUNKNOWN Panel Members
Feb 9, 2012·Expert Opinion on Therapeutic Targets·Yi-long Wu, Qing Zhou
Apr 25, 2015·Expert Opinion on Pharmacotherapy·E-E KeYi-Long Wu
Aug 8, 2013·Experimental Lung Research·Ning XiaCheng-ping Hu
Mar 4, 2015·Expert Opinion on Drug Metabolism & Toxicology·Gerhard HamiltonOtto Burghuber
Sep 10, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yan WangJun Zhang
Feb 15, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Lynette M ShollJason L Hornick
Feb 15, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Antonio MarchettiCarmine Pinto
Mar 2, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jennifer M BolandEunhee S Yi
Feb 13, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Florian CabillicMarc-Antoine Belaud-Rotureau
Oct 19, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sanjay PopatMary E R O'Brien
Nov 30, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Shang-Gin WuPan-Chyr Yang
Dec 3, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ping YangEunhee S Yi
Dec 19, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tianhong LiDavid R Gandara

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Methods Mentioned

BETA
PCR
electrophoresis
M13 sequencing

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