Fusion of piggyBac -like transposons and herpesviruses occurs frequently in teleosts

Zoological Letters
Yusuke InoueHiroyuki Takeda

Abstract

Endogenous viral elements play important roles in eukaryotic evolution by giving rise to genetic novelties. Herpesviruses are a large family of DNA viruses, most of which do not have the ability to endogenize into host genomes. Recently, we identified a novel type of endogenous herpesvirus, which we named "Teratorn", from the medaka (Oryzias latipes) genome, in which the herpesvirus is fused with a piggyBac-like DNA transposon, forming a novel mobile element. Teratorn is a unique herpesvirus that retains its viral genes intact and has acquired the endogenized lifestyle by hijacking the transposon system. However, it is unclear how this novel element evolved in the teleost lineage and whether fusion of two mobile elements is a general phenomenon in vertebrates. Here we performed a comprehensive genomic survey searching for Teratorn-like viruses in publicly available genome data and found that they are widely distributed in teleosts, forming a clade within Alloherpesviridae. Importantly, at least half of the identified Teratorn-like viruses contain piggyBac-like transposase genes, suggesting the generality of the transposon-herpesvirus fusion in teleosts. Phylogenetic tree topologies between the piggyBac-like transposase gene and...Continue Reading

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Citations

Feb 24, 2019·Genome Biology and Evolution·Irina R Arkhipova, Irina A Yushenova
Jan 23, 2021·Molecular Biology and Evolution·Jose Gabriel Nino Barreat, Aris Katzourakis
Apr 21, 2021·Genome Research·Aaron A VoganHanna Johannesson

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