PMID: 7539287Apr 1, 1995Paper

Fusion of the EWS gene to a DNA segment from 9q22-31 in a human myxoid chondrosarcoma

Genes, Chromosomes & Cancer
S GillJ M Shipley

Abstract

Southern blot analyses revealed a rearrangement of the EWS gene in a skeletal human myxoid chondrosarcoma. Interphase fluorescence in situ hybridization (FISH) studies, using cosmid clones F7 and G9 that flank the EWS locus on 22q12, confirmed the presence of this EWS gene abnormality. Cloning the rearranged EWS DNA fragment and mapping by FISH demonstrated that the EWS gene is joined to DNA sequences localised in 9q22-31. These findings are consistent with previous cytogenetic reports of a recurrent t(9;22)(q22-31;q11-12) in the myxoid variant of chondrosarcoma and reveal involvement of the EWS gene in a fourth type of human sarcoma.

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May 20, 1999·American Journal of Ophthalmology·C M MooyD A Paridaens
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