Fusion pore regulation in peptidergic vesicles

Cell Calcium
Jernej JorgacevskiRobert Zorec

Abstract

Regulated exocytosis, which involves fusion of secretory vesicles with the plasma membrane, is an important mode of communication between cells. In this process, signalling molecules that are stored in secretory vesicles are released into the extracellular space. During the initial stage of fusion, the interior of the vesicle is connected to the exterior of the cell with a narrow, channel-like structure: the fusion pore. It was long believed that the fusion pore is a short-lived intermediate state leading irreversibly to fusion pore dilation. However, recent results show that the diameter of the fusion pore can fluctuate, suggesting that the fusion pore is a subject of stabilization. A possible mechanism is addressed in this article, involving the local anisotropicity of membrane constituents that can stabilize the fusion pore. The molecular nature of such a stable fusion pore to predict how interacting molecules (proteins and/or lipids) mediate changes that affect the stability of the fusion pore and exocytosis is also considered. The fusion pore likely attains stability via multiple mechanisms, which include the shape of the lipid and protein membrane constituents and the interactions between them.

References

Oct 1, 1988·Trends in Neurosciences·S J Smith, G J Augustine
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W S TrimbleR H Scheller
May 1, 1973·The Journal of Cell Biology·B CeccarelliA Mauro
May 1, 1974·Genetics·S Brenner
Sep 1, 1967·The Journal of Physiology·B Katz, R Miledi
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E Neher, A Marty
Feb 1, 1996·Biophysical Journal·T J SchroederR M Wightman
Nov 14, 1996·Nature·B L Sabatini, W G Regehr
Feb 7, 1998·The Journal of Biological Chemistry·A TitievskyK Törnquist
Aug 17, 1999·The EMBO Journal·I DulubovaJ Rizo
Jan 5, 2000·Journal of Immunological Methods·K Lollike, M Lindau
Feb 7, 2001·Science·R J FisherR D Burgoyne
May 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·L H ChamberlainG W Gould
Jun 12, 2001·Current Opinion in Neurobiology·G J Augustine
Aug 11, 2001·Biochemical Society Transactions·R D BurgoyneA Morgan
Sep 8, 2001·Neuron·T VoetsM Verhage
Mar 29, 2003·Physiological Reviews·Robert D Burgoyne, Alan Morgan
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Keith WeningerAxel T Brunger
Jun 8, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Matjaz StenovecRobert Zorec
Sep 16, 2004·Nature Reviews. Molecular Cell Biology·Lynne Chang, Robert D Goldman
Oct 13, 2005·Journal of Cell Science·Matthew A ChurchwardJens R Coorssen
Nov 29, 2005·Journal of Chemical Information and Modeling·Miha FosnaricSylvio May
May 2, 2006·Biophysical Journal·W LiuVladimir Parpura
Jun 30, 2006·Journal of Neurochemistry·Nobutoshi C HarataRichard W Tsien

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Citations

Dec 19, 2012·Annual Review of Physiology·AbdulRasheed A Alabi, Richard W Tsien
Sep 19, 2012·Cellular and Molecular Life Sciences : CMLS·Natalie Porat-ShliomRoberto Weigert
Jul 13, 2012·Cell Calcium·Jens R Coorssen, Robert Zorec
Feb 5, 2016·Journal of Neurochemistry·Marko KreftRobert Zorec

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