Fut3 role in breast invasive ductal carcinoma: Investigating its gene promoter and protein expression

Experimental and Molecular Pathology
Jessica Catarine Frutuoso do NascimentoEduardo I C Beltrão

Abstract

Fucosylated glycans synthesized by α1,3/4-fucosyltransferase (FUT3) enzyme play an important role in breast cancer prognosis and metastasis, being involved in the binding of circulating tumor cells to the endothelium and being related to tumor stage, metastatic potential and chemoresistance. Despite the pro-tumor action of this enzyme, studies have demonstrated its role in natural killer-induced cytotoxicity through the recognition of sialyl Lewis X by C-type lectin receptors and through extrinsic apoptosis pathway triggered by Apo2L-TRAIL. This study aimed to investigate the expression pattern of FUT3 in invasive breast carcinoma (IDC) from patients of Pernambuco state, Northeast of Brazil, and genotype FUT3 promoter region to identify possible SNPs that could be associated with variations in FUT3 expression. Immunohistochemistry assay was used to access the FUT3 expression in normal (n=11) and tumor tissues (n=85). DNA sequencing was performed to genotype the FUT3 promoter region in patients with IDC (n=109) and healthy controls (n=110). Our results demonstrated that the absence of FUT3 enzyme is related to breast's IDC. The non-expression of FUT3 was more frequent in larger lesions and also in HER2 negative IDC tumors. Genom...Continue Reading

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Citations

May 5, 2020·Glycobiology·Krzysztof MikolajczykMarcin Czerwinski
Feb 18, 2020·Glycoconjugate Journal·Jessica Catarine Frutuoso do NascimentoCíntia Renata Costa Rocha
Apr 1, 2019·Molecular Biology Reports·Jessica Catarine Frutuoso do NascimentoCíntia Renata Costa Rocha
Jun 19, 2019·Cancer Gene Therapy·Yifeng DaiLin Fu
Sep 29, 2019·Critical Reviews in Oncology/hematology·Sonia How Ming WongSiew Ching Ngai

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