PMID: 6407778Aug 1, 1983Paper

Future directions for nonclinical evaluation

Circulation
W B Hood

Abstract

Much of our knowledge about the effects of coronary occlusion and reperfusion is derived from studies in experimental animals. The recent discovery that coronary thrombosis is usually present in clinical myocardial infarction and that thrombolysis represents an approach to therapy presents opportunities for further experimental work. Animal models are particularly suited to the study of pathogenesis of thrombus formation in atherosclerotic vessels, the role of coronary vasomotor tone, and the effects of restoration of flow upon ischemic myocardium. Although the value of thrombolytic therapy must be proved in the clinical setting, animal models provide an important resource for the study of basic mechanisms.

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.