Future Directions of Marine Myxobacterial Natural Product Discovery Inferred from Metagenomics

Marine Drugs
Ronald GarciaRolf Müller

Abstract

Over the last two decades, halophilic (organisms that thrive at high salt concentrations) and halotolerant (organisms that have adapted to high salt concentrations) myxobacteria emerged as an important source of structurally diverse secondary metabolites from the marine environment. This review explores the advance of metagenomics analysis and 16S rRNA gene phylogeny of the cultured and uncultured myxobacteria from marine and other salt-environments up to July 2018. The diversity of novel groups of myxobacteria in these environments appears unprecedented, especially in the Sorangiineae and Nannocystineae suborders. The Sandaracinaceae related clade in the Sorangiineae suborder seems more widely distributed compared to the exclusively marine myxobacterial cluster. Some of the previously identified clones from metagenomic studies were found to be related to the Nannocystineae suborder. This understanding provides the foundation for a vital, unexplored resource. Understanding the conditions required to cultivate these yet "uncultured" myxobacteria in the laboratory, while a key next step, offers a significant potential to further expand access to diverse secondary metabolites.

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Citations

Dec 6, 2019·Frontiers in Microbiology·Megan M MullisBrandi Kiel Reese
Sep 8, 2018·Marine Drugs·Katja GemperleinRolf Müller
Nov 15, 2020·Applied and Environmental Microbiology·Lu WangRyan S Mueller
Mar 9, 2021·Computational and Structural Biotechnology Journal·Raghav VijSascha Brunke
May 19, 2021·Journal of Industrial Microbiology & Biotechnology·Dorothy A OkothRolf Müller
Jul 15, 2021·Microbiology Spectrum·Jingjing WangYuezhong Li

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Datasets Mentioned

BETA
AB246767
AB246768
KP174648
JF344537
KR825029
KX097196
AY225609
JF344693
U15117
FJ905758

Software Mentioned

BLAST

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