Future horizons in the treatment of enteric neuropathies

Journal of Pediatric Gastroenterology and Nutrition
Nikhil Thapar

Abstract

Enteric neuropathies comprise a vast and disparate array of congenital and acquired disorders of the enteric nervous system (ENS), reflecting both the complexity of its neuronal composition and the many interactions that modulate its function. Although present therapeutic strategies, largely limited to surgery and the provision of artificial nutrition, have transformed the early survival and life of sufferers, levels of morbidity and mortality remain unacceptably high. This highlights the need to develop new treatments for enteric neuropathies. In the last decade, the tremendous advances in molecular biology and genetics have significantly enhanced our understanding of ENS development and function. Coupled with equivalent progress in the fields of pharmacology and stem-cell biology, this has led to the identification of novel tools and targets for therapy, which either aim to optimise the function of the intrinsic ENS or replace/replenish components of an inadequate or dysfunctional ENS. This article reviews current work on a number of these interventions with a particular focus on the use of ENS stem cells as potential therapeutic tools for enteric neuropathies.

References

Apr 1, 1988·Pediatric Clinics of North America·P J Milla
Feb 18, 1999·Journal of Pediatric Surgery·H TsujiA Pierro
Mar 18, 1999·Baillière's Clinical Gastroenterology·P J Milla
Apr 15, 1999·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·P J Milla
Jun 18, 1999·Archives of Disease in Childhood·S HeneykeP J Milla
Jun 16, 2000·International Journal of Colorectal Disease·A ShafikA A Shafik
Jun 28, 2000·Journal of the Autonomic Nervous System·J B Furness
Sep 21, 2000·Transplantation Proceedings·S V BeathJ de Ville de Goyet
Jan 11, 2001·Developmental Biology·H M YoungD F Newgreen
Jul 10, 2002·Gastroenterology·Jörg GlatzleHelen E Raybould
Aug 23, 2002·Journal of Pediatric Gastroenterology and Nutrition·Peter MillaTakeshi Tomomasa
Oct 25, 2002·Digestive Diseases and Sciences·Hayat MousaCarlo Di Lorenzo
Dec 10, 2002·Pediatric Surgery International·E L SidebothamD H Edgar
Jun 28, 2003·Pharmacology & Toxicology·Mark Berner Hansen
Apr 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A J BurnsH M Young
Apr 7, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R De GiorgioR Corinaldesi
Jun 10, 2004·Gastroenterology·Roberto De GiorgioGary M Mawe
Oct 27, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R De Giorgio, M Camilleri
Mar 25, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G BogeskiJ B Furness
Mar 25, 2005·Science of Aging Knowledge Environment : SAGE KE·Paul R Wade, Pamela J Hornby
May 28, 2005·Transplantation Proceedings·O GouletY Revillon
Feb 8, 2006·Current Opinion in Gastroenterology·David Grundy, Michael Schemann
Feb 14, 2006·Gastroenterology·Deirdre A Kelly
Mar 22, 2006·Acta Haematologica·Shoshana Revel-Vilk
Apr 12, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Olivier Goulet, Frédérique Sauvat
May 18, 2006·Archives of Disease in Childhood·Girish L GupteDeirdre A Kelly
Jun 13, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F W GuglielmiA Francavilla
Jul 14, 2006·Current Treatment Options in Gastroenterology·Jing Zhang, J D Z Chen
Aug 16, 2006·Transplantation Proceedings·F SauvatO Goulet
Aug 24, 2006·Transplantation·Louise LongworthMartin J Buxton

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Citations

Nov 4, 2011·Pediatric Surgery International·Cornelia Irene HaglKarl-Herbert Schäfer
Feb 9, 2012·International Journal of Colorectal Disease·Cornelia Irene HaglKarl-Herbert Schäfer
Jun 28, 2012·BMC Gastroenterology·Valentina SasselliPankaj Jay Pasricha
Feb 13, 2013·Nature Reviews. Gastroenterology & Hepatology·Charles H KnowlesRoberto De Giorgio
Mar 28, 2009·Journal of Pediatric Gastroenterology and Nutrition·Nikhil Thapar

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