Future of human mitochondrial DNA editing technologies

Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
N VerechshaginaI O Mazunin

Abstract

ATP and other metabolites, which are necessary for the development, maintenance, and functioning of bodily cells are all synthesized in the mitochondria. Multiple copies of the genome, present within the mitochondria, together with its maternal inheritance, determine the clinical manifestation and spreading of mutations in mitochondrial DNA (mtDNA). The main obstacle in the way of thorough understanding of mitochondrial biology and the development of gene therapy methods for mitochondrial diseases is the absence of systems that allow to directly change mtDNA sequence. Here, we discuss existing methods of manipulating the level of mtDNA heteroplasmy, as well as the latest systems, that could be used in the future as tools for human mitochondrial genome editing.

References

May 1, 2001·Biochemical and Biophysical Research Communications·Y HashimotoI Nishimoto
Oct 10, 2002·Journal of Biomedical Science·Masashi TanakaKunio Yagi
Oct 22, 2003·Molecular Genetics and Metabolism·Victoria Del GaizoR Mark Payne
Aug 12, 2005·Cytogenetic and Genome Research·B C LampsonS Inouye
Dec 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michal MinczukAaron Klug
Jan 9, 2008·American Journal of Human Genetics·Amy K ReeveDouglass M Turnbull
Dec 20, 2008·Human Molecular Genetics·Hirokazu Fukui, Carlos T Moraes
Aug 28, 2009·Nature·Masahito TachibanaShoukhrat Mitalipov
Aug 10, 2010·Cell·Geng WangMichael A Teitell
Apr 24, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hong YuJohn Guy
Jun 30, 2012·Science·Martin JinekEmmanuelle Charpentier
Sep 21, 2012·Nature Reviews. Molecular Cell Biology·Lawrence KazakIan J Holt
Oct 12, 2013·Human Mutation·Joana DamasFilipe Pereira
Feb 18, 2014·Cell·Hiroshi NishimasuOsamu Nureki
Aug 5, 2014·Cell Metabolism·B Martin Hällberg, Nils-Göran Larsson
Aug 26, 2014·Progress in Molecular Biology and Translational Science·Konstantin Khrapko, Doug Turnbull
Nov 25, 2014·Methods in Enzymology·Sandra R BacmanCarlos T Moraes
Dec 30, 2014·Biochemistry. Biokhimii︠a︡·M V PatrushevI O Mazunin
Jan 30, 2015·Methods in Molecular Biology·Geng WangMichael A Teitell
Jan 31, 2015·Methods in Molecular Biology·Ilya DovydenkoNina Entelis
Apr 25, 2015·Cell·Pradeep ReddyJuan Carlos Izpisua Belmonte
Jun 23, 2015·Nature·Benjamin P KleinstiverJ Keith Joung
Jul 15, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Masami HashimotoCarlos T Moraes
Oct 9, 2015·BioMed Research International·Areum JoYunjong Lee
Nov 3, 2015·Nature Biotechnology·Benjamin P KleinstiverJ Keith Joung
Mar 30, 2016·Annual Review of Biochemistry·Claes M GustafssonNils-Göran Larsson
Apr 27, 2016·Cell·Takashi YamanoOsamu Nureki
May 12, 2016·Cell Metabolism·Alexander N PatanananMichael A Teitell
May 25, 2016·Free Radical Biology & Medicine·Changhan LeePinchas Cohen

❮ Previous
Next ❯

Citations

Sep 6, 2018·IUBMB Life·Romuald LoutreIvan Tarassov
Dec 4, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anna Klucnika, Hansong Ma
Sep 6, 2020·International Journal of Molecular Sciences·Yuma YamadaHideyoshi Harashima
May 28, 2020·Frontiers in Genetics·Ruaidhri CappaAmy J McKnight
Sep 12, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yuma YamadaHideyoshi Harashima

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.