Future perspectives for optimizing oral antiplatelet therapy

Cerebrovascular Diseases
J Donald Easton

Abstract

Secondary prevention of stroke and other manifestations of atherothrombosis is essential if the burden of disease associated with these events is to be reduced. Therefore, it is important to identify patients most likely to benefit from antiplatelet therapy. There is a good rationale for combining antiplatelet agents with different modes of action, since different signalling pathways contribute to platelet activation. Based on the promising results obtained with an adenosine diphosphate receptor antagonist-aspirin combination in coronary stenting, several additional trials with clopidogrel plus aspirin are ongoing. They include CURE (Clopidogrel in Unstable angina to prevent Recurrent Events, in unstable angina and non-Q-wave myocardial infarction) and COMMIT (in acute myocardial infarction), which compare clopidogrel with placebo in patients receiving aspirin, and CREDO (Clopidogrel for Reduction of Events During extended Observation), a 1-year treatment follow-up to the clopidogrel arms of the CLASSICS trial (Clopidogrel Aspirin Stent International Cooperative Study). Planned trials with clopidogrel in neurology include SPS3 (Secondary Prevention of Small Subcortical Strokes, in patients with symptomatic lacunar stroke), and ...Continue Reading

Citations

Feb 12, 2005·Cardiology in Review·Bradley A MaronJ Donald Easton
Sep 1, 2009·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Emir MujanovicJacob Bergsland
Feb 14, 2003·Current Cardiology Reports·Cathy M Helgason
Feb 5, 2002·Expert Opinion on Pharmacotherapy·K M Crawford, R L Talbert
Mar 1, 2002·Expert Review of Neurotherapeutics·Thomas Mooe

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