Future Perspectives on the Role of Stem Cells and Extracellular Vesicles in Vascular Tissue Regeneration

Frontiers in Cardiovascular Medicine
Eoghan M CunnaneDavid A Vorp

Abstract

Vascular tissue engineering is an area of regenerative medicine that attempts to create functional replacement tissue for defective segments of the vascular network. One approach to vascular tissue engineering utilizes seeding of biodegradable tubular scaffolds with stem (and/or progenitor) cells wherein the seeded cells initiate scaffold remodeling and prevent thrombosis through paracrine signaling to endogenous cells. Stem cells have received an abundance of attention in recent literature regarding the mechanism of their paracrine therapeutic effect. However, very little of this mechanistic research has been performed under the aegis of vascular tissue engineering. Therefore, the scope of this review includes the current state of TEVGs generated using the incorporation of stem cells in biodegradable scaffolds and potential cell-free directions for TEVGs based on stem cell secreted products. The current generation of stem cell-seeded vascular scaffolds are based on the premise that cells should be obtained from an autologous source. However, the reduced regenerative capacity of stem cells from certain patient groups limits the therapeutic potential of an autologous approach. This limitation prompts the need to investigate allo...Continue Reading

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Citations

Jul 11, 2019·Stem Cells Translational Medicine·Golnar ShojaatiJames L Funderburgh
Jan 23, 2020·International Journal of Molecular Sciences·Yong Weon YiByong Seung Cho
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Apr 23, 2021·Journal of Biological Engineering·Nicolai SeiffertBenjamin Struecker
Sep 10, 2020·Analytical Chemistry·Ayemeh Bagheri HashkavayiKi Soo Park
May 23, 2020·ACS Applied Materials & Interfaces·Eoghan M CunnaneDavid A Vorp
Oct 12, 2021·Technology in Cancer Research & Treatment·Sai Priyanka Kodam, Mujib Ullah

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