Future role of thrombolytic therapy in emergency medicine

Annals of Emergency Medicine
M J Bresler

Abstract

Thrombolytic therapy offers the promise of major therapeutic intervention in many areas as well as in the treatment of patients with acute myocardial infarction who present to the emergency department. Infusion of tissue-type plasminogen activator (tPA) during field transport has been proven safe, but optimal methods for reliably diagnosing acute myocardial infarction in the prehospital setting have yet to be delineated. A major advance would be achieved if thrombolysis were proven effective in preventing the progression of unstable angina to actual infarction. However, early studies have yielded contradictory results. The use of tPA in dissolving peripheral arterial clots appears very promising, but long-term limb survival has yet to be demonstrated. Unlike heparin, thrombolytic agents can also lyse clot in peripheral deep veins and possibly lessen the tendency toward postphlebitic syndrome. The proper dosage regimen to minimize hemorrhage has not been determined. Pulmonary emboli can be lysed by tPA. IV infusion is as effective as intrapulmonary. Significant complications can be minimized, particularly if major vessel catheterization can be avoided for diagnosis. Even after catheterization for pulmonary angiography, however, ...Continue Reading

References

Nov 20, 1975·The New England Journal of Medicine·J C FratantoniT L Simon
Dec 15, 1988·Annals of Internal Medicine·E J Topol
Nov 1, 1987·Journal of the American College of Cardiology·S Z GoldhaberJ Loscalzo
Nov 1, 1988·Annals of Emergency Medicine·G J del Zoppo
Nov 1, 1988·Annals of Emergency Medicine·T BrottJ R Marler
Nov 1, 1988·Annals of Emergency Medicine·J W Olin, R A Graor
Oct 1, 1987·Journal of the American College of Cardiology·E BraunwaldR Solomon
Apr 1, 1985·AJR. American Journal of Roentgenology·T O McNamara, J R Fischer
Apr 1, 1974·Radiology·C T DotterA J Seaman
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B K Siesjö

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Citations

Jan 1, 1993·The Journal of Emergency Medicine·S H ThomasE J Allison

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