Future therapeutics for the induction of peripheral immune tolerance in autoimmune disease and organ transplantation

Immunotherapy
Stephen Cobbold

Abstract

Rodent models of transplantation and autoimmune disease have demonstrated that it is possible to induce lifelong and specific immunological tolerance to both self and graft antigens in the absence of any continued immunosuppression. If this situation could be achieved clinically, it would avoid many of the longer-term complications of immunosuppression, such as the increased risk of infection, cancer and other side effects, such as nephrotoxicity. In this review, we shall consider the interplay between regulatory T cells, dendritic cells and the tissue itself, and the resulting local protective mechanisms that are coordinated to maintain the tolerant state and an acquired local immune privilege. The current status of attempts to apply tolerogenic approaches to the clinical treatment of autoimmune diseases and to induce either tolerance to organ grafts or sufficient immune regulation so that conventional immunosuppression can be minimized will also be considered.

References

Dec 1, 1992·The Journal of Experimental Medicine·P S LinsleyN K Damle
Jun 1, 1986·The Journal of Experimental Medicine·R J BenjaminH Waldmann
Dec 1, 1981·Transplantation·A B CosimiP S Russell
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·D C ParkerA A Rossini
Oct 1, 1994·The Journal of Experimental Medicine·J Sloan-LancasterP M Allen
Feb 12, 1993·Science·S QinH Waldmann
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·L ChatenoudJ F Bach
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·A D KirkS J Knechtle
Nov 21, 1997·Clinical and Experimental Immunology·J D IsaacsH Waldmann
May 16, 1998·European Journal of Immunology·S M Anderton, D C Wraith
Dec 10, 1999·Journal of the American Society of Nephrology : JASN·P K DattaE A Lianos
Dec 28, 1999·Microbes and Infection·H Strobl, W Knapp
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·O AnnackerA Bandeira
Feb 27, 2001·Nature Immunology·Y LatchmanG J Freeman
Mar 13, 2001·Annual Review of Immunology·B Salomon, J A Bluestone
May 26, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H WaldmannS Cobbold
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H HacksteinA W Thomson
Jun 29, 2001·Trends in Immunology·H JonuleitA H Enk
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S GregoriL Adorini
Nov 28, 2001·Immunological Reviews·L ChatenoudJ A Bluestone
Nov 28, 2001·Immunological Reviews·B SinghF Powrie
Dec 12, 2001·Nature Immunology·Marc A GavinAlexander Rudensky
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Diana ZelenikaHerman Waldmann
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paola RomagnoliJoost P M van Meerwijk
Feb 22, 2002·European Journal of Immunology·LauraL CarterBeatriz M Carreno
Mar 20, 2002·Current Molecular Medicine·F P Huang, G G MacPherson
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luis GracaHerman Waldmann
Jun 19, 2002·The Journal of Experimental Medicine·Luis GracaHerman Waldmann

❮ Previous
Next ❯

Citations

Nov 8, 2012·Future Oncology·Jessica A CintoloBrian J Czerniecki
May 16, 2019·Oxidative Medicine and Cellular Longevity·Robert SucherJohanna M Gostner

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
glycosylation

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.