Future use of mitocans against tumour-initiating cells?

Molecular Nutrition & Food Research
Brian J MorrisonJiri Neuzil

Abstract

Tumour heterogeneity has several important consequences including: (i) making their classification by morphological and genetic analysis more difficult because of the diversity within single tumours and the common majority of cells as the bulk of a tumour will dominate this classification whether or not these cells are critical for diagnosis or treatment, (ii) treatments may fail to eradicate tumours simply by failing to eliminate one of the cell subtypes within the tumour and (iii) differing abilities of the cell subtypes for dissemination and metastasis. Recently, a rare subpopulation of cells within tumours has been described with the ability to initiate and sustain tumour growth, to resist traditional therapies and to allow for secondary tumour dissemination. These cells are termed tumour-initiating cells (TICs). Understanding tumour heterogeneity will be critical for advancing treatments for cancer that target TIC subpopulations of cells in a tumour able to resist traditional treatments and eliminate them before metastatic disease occurs. It follows that the TICs will be the most important cellular components in the tumour target. Therefore, knowledge of the molecular mechanism(s) of resistance of TICs to treatment and ove...Continue Reading

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Citations

Apr 21, 2011·Antioxidants & Redox Signaling·Renata ZobalovaJiri Neuzil
Jul 6, 2010·Mitochondrion·Lucia BiasuttoJiri Neuzil
Dec 10, 2009·Molecular Aspects of Medicine·Feng WangPeng Huang
Dec 25, 2013·Nutrition and Cancer·Aracely Angulo-MolinaJesús Hernández
Nov 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sophie HoenkeRené Csuk

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