Aug 16, 2006

FXR, a multipurpose nuclear receptor

Trends in Biochemical Sciences
Florence Ying LeeYanqiao Zhang

Abstract

The farnesoid X receptor (FXR) is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. In the past six years, remarkable inroads have been made into determining the functional importance of FXR. This receptor has been shown to have crucial roles in controlling bile acid homeostasis, lipoprotein and glucose metabolism, hepatic regeneration, intestinal bacterial growth and the response to hepatotoxins. Thus, the development of FXR agonists might prove useful for the treatment of diabetes, cholesterol gallstones, and hepatic and intestinal toxicity.

Mentioned in this Paper

LDLR wt Allele
Takifugu rubripes
Biochemical Pathway
Sterol 12-alpha-Hydroxylase
Insulin Sensitivity
Lipoprotein Metabolic Process
Bile Acid Measurement
ABCB4 gene
Teleost fish
Amino Acids, I.V. solution additive

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