PMID: 25772759Mar 17, 2015Paper

FZD6 expression is negatively regulated by miR-199a-5p in human colorectal cancer

BMB Reports
Bong-Kyu KimSungjoo Kim Yoon

Abstract

Colorectal cancer (CRC), the third most common cancer worldwide, also has the highest rate of cancer-related morbidity and mortality. WNT signaling is initiated by binding of WNT to various receptors, including frizzleds (FZDs), and plays a critical role in CRC and other tumor development by regulating proliferation, differentiation, migration, apoptosis, and polarity. Among the members of the FZD family, FZD6 is broadly expressed in various tissues, and its overexpression has been reported in several cancers, suggesting an important role in cancer development. In this study, we investigated the expression of FZD6 in patients with CRC and found it to be increased in tumors, as compared to paired adjacent non-tumor tissues. Additionally, we found that FZD6 expression was negatively regulated by miR199a5p in CRC cells. These results suggest that overexpression of FZD6, mediated by reduced expression of miR-199a-5p, may play an important role in the development of CRC.

References

Mar 3, 1998·Biochemical and Biophysical Research Communications·M TokuharaM Katoh
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·S TanakaK Sugimachi
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jul 31, 2002·Molecular Pathology : MP·R F HolcombeT Truong
Jul 9, 2004·Genome Biology·Hui-Chuan Huang, Peter S Klein
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Catriona Y Logan, Roel Nusse
Jan 29, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jinmai JiangThomas D Schmittgen
May 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eun Ji NamSunghoon Kim
Jul 2, 2008·Neoplasia : an International Journal for Oncology Research·Koji UenoYuji Hinoda
Apr 15, 2009·Cell Research·Shih-Lei LaiRandall T Moon
May 1, 2010·Lancet·Wendy S AtkinUNKNOWN UK Flexible Sigmoidoscopy Trial Investigators
Jun 11, 2010·Annual Review of Biochemistry·Marc Robert FabianWitold Filipowicz
Sep 3, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jan KrützfeldtMarkus Stoffel
Jul 27, 2012·International Journal of Cancer. Journal International Du Cancer·Koji UenoRajvir Dahiya
Nov 21, 2013·PloS One·Sze Chuen Cesar WongAnthony Tak Cheung Chan
Nov 28, 2013·BMC Cancer·Beatriz García-CastroAdriana Aguilar-Lemarroy
Jan 23, 2014·Journal of Dermatological Science·Bong-Kyu KimSungjoo K Yoon
Oct 15, 2014·PloS One·Jiugang SongDaiming Fan

❮ Previous
Next ❯

Citations

Oct 14, 2016·Journal of Human Genetics·Nijiro NohataJ Silvio Gutkind
Nov 11, 2016·BMC Genomics·Daisuke KomuraShumpei Ishikawa
Jan 17, 2017·Journal of Cellular Physiology·Abdullah MoridikiaJafar Salimian
May 10, 2018·Bioscience, Biotechnology, and Biochemistry·Fumina Ohsaka, Kei Sonoyama
May 24, 2018·International Journal of Molecular Sciences·Chui-Mian ZengLi Fu
Mar 25, 2020·Critical Reviews in Biochemistry and Molecular Biology·Linxi LiC Yan Cheng
Jun 30, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Stefanie ThieleLorenz C Hofbauer
Mar 7, 2017·Cell Biochemistry and Function·Guo-Hao HuangPeng-Fei Pang
May 29, 2018·Technology in Cancer Research & Treatment·Qian Dong ZhuXia Deng
Nov 22, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J ZhangY-Y Wang
Jan 11, 2020·Frontiers in Bioengineering and Biotechnology·S Udhaya KumarHatem Zayed
Jul 3, 2019·Cancers·Irantzu Gorroño-EtxebarriaRobert M Kypta
Aug 13, 2021·Journal of Biochemical and Molecular Toxicology·Meisam Jafarzadeh, Bahram M Soltani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

International Journal of Cancer. Journal International Du Cancer
Koji UenoRajvir Dahiya
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Haizhou GuoZhangsuo Liu
Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer
Li LiuWilliam Rom
© 2021 Meta ULC. All rights reserved