G-308A polymorphism of the tumor necrosis factor alpha gene promoter and salivary cortisol secretion

The Journal of Clinical Endocrinology and Metabolism
Roland RosmondPer Björntorp

Abstract

The objective of the current study was to examine the potential impact of the G-->A substitution at position -308 of the tumor necrosis factor alpha (TNF-alpha) gene promoter on obesity and estimates of insulin, glucose, and lipid metabolism as well as circulating hormones including salivary cortisol in 284 unrelated Swedish men born in 1944. The subjects were genotyped by using PCR amplification of the 5' untranslated region of the TNF-alpha gene followed by digestion with the restriction enzyme NcoI. The frequencies were 0.77 for allele G and 0.23 for allele A. Tests for differences in salivary cortisol levels between the TNF-alpha genotypes revealed that there were significantly higher cortisol levels in the morning, before as well as 30 and 60 min after stimulation by a standardized lunch in homozygotes for the rare allele in comparison with the other genotypes. In addition, homozygotes for the rare allele had a tendency toward higher mean values of body mass index, waist to hip ratio, and abdominal sagittal diameter compared with the other genotype groups. The results also indicated a weak trend toward elevated insulin and glucose levels among men with the A/A genotype. In conclusion, a G-->A polymorphism in the 5' untrans...Continue Reading

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Citations

Jul 28, 2011·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Hannan Al-RayesMohammad Tariq
Mar 12, 2002·Obesity Research·Tuomo RankinenClaude Bouchard
Sep 27, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·R Rosmond

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