G-CSF is a key modulator of MDSC and could be a potential therapeutic target in colitis-associated colorectal cancers

Protein & Cell
Wenbin LiJie Ma

Abstract

Granulocyte colony-stimulating factor (G-CSF) is an essential regulator of neutrophil trafficking and is highly expressed in multiple tumors. Myeloid derived suppressor cells (MDSCs) promote neoplastic progression through multiple mechanisms by immune suppression. Despite the findings of G-CSF function in colon cancer progression, the precise mechanism of G-CSF on MDSCs regulation and its blockade effects on tumor growth remains a worthy area of investigation. In this study we observed an overexpression of G-CSF in a mouse colitis-associated cancer (CAC) model, which was consistent with the accumulation of MDSCs in mouse colon tissues. Further in vitro studies demonstrated that G-CSF could promote MDSCs survival and activation through signal transducer and activator of transcription 3 (STAT3) signaling pathway. Moreover, compared with isotype control, anti-G-CSF mAb treatment demonstrated reduced MDSC accumulation, which led to a marked decrease in neoplasm size and number in mice. Our results indicated that G-CSF is a critical regulating molecule in the migration, proliferation and function maintenance of MDSCs, which could be a potential therapeutic target for colitis-associated cancer.

References

Oct 3, 2002·Biochemical and Biophysical Research Communications·Takeshi NatoriMasatoshi Makuuchi
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sergei KusmartsevDmitry I Gabrilovich
Feb 12, 2004·Cancer Research·Qingsheng LiShu-Hsia Chen
Aug 3, 2004·Nature Medicine·Bert Vogelstein, Kenneth W Kinzler
Aug 9, 2005·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Taku YokoyamaKen Saitoh
Dec 3, 2005·Nature Reviews. Immunology·Siamon Gordon, Philip R Taylor
Oct 13, 2007·Science·Laura D WoodBert Vogelstein
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Je-In YounDmitry I Gabrilovich
Feb 7, 2009·Nature Reviews. Immunology·Dmitry I Gabrilovich, Srinivas Nagaraj
Aug 25, 2009·The International Journal of Biochemistry & Cell Biology·Clifford LiongueAlister C Ward
Jun 4, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sibylle von VietinghoffKlaus Ley
Nov 29, 2011·Cancer Immunology, Immunotherapy : CII·Paola FilipazziLicia Rivoltini
Jul 4, 2012·Oncoimmunology·Scott I Abrams, Jeremy D Waight
Dec 12, 2012·Journal of Clinical Immunology·Juliana Candido, Thorsten Hagemann
Jan 18, 2013·The New England Journal of Medicine·Awen M Gallimore, Andrew Godkin
Oct 24, 2014·Annual Review of Medicine·Thomas CondamineDmitry I Gabrilovich

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Citations

Nov 3, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mengchen ZhuJianjun Zhou
Oct 5, 2017·ELife·Lukas Franz MagerPhilippe Krebs
Jan 26, 2018·Journal of Thrombosis and Haemostasis : JTH·L ServaisC Oury
Nov 7, 2019·Journal for Immunotherapy of Cancer·Philipp MetzgerPeter Duewell
May 18, 2020·American Journal of Reproductive Immunology : AJRI·Zi-Meng ZhengJun Shao
Oct 24, 2018·Frontiers in Immunology·Emile J ClappaertDamya Laoui
Feb 23, 2017·Journal of Translational Medicine·Yana G NajjarAhmad A Tarhini
Mar 19, 2020·Molecular Medicine Reports·Li LiuXiangyang Xiong
Aug 24, 2019·Cancer Immunology Research·Charles S TannenbaumC Marcela Diaz-Montero
Jan 8, 2021·Cancer Metastasis Reviews·Kathryn ColeJames E Talmadge
Mar 8, 2021·Cytokine·Ioannis KaragiannidisEllen J Beswick
Jul 18, 2020·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Nuray ErinThomas Efferth
Mar 28, 2021·Cancer Communications·Cheng CuiLi Fu
May 1, 2021·International Journal of Molecular Sciences·Izabela SiemińskaJarek Baran
May 13, 2021·Journal of Applied Toxicology : JAT·Adam HargreavesShirley Price
Oct 9, 2021·Signal Transduction and Targeted Therapy·Kai LiYongsheng Wang
Nov 14, 2021·International Journal of Clinical Oncology·Keywan Mortezaee, Jamal Majidpoor

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Methods Mentioned

BETA
protein-chip
PCR
ELISA
Flow cytometry
Fluorescence-activated cell sorting
protein
protein array
chips
chip
dissection

Software Mentioned

FlowJo
TLuxScan
CellQuestPro

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