G-CSF mobilised granulocyte transfusions in 32 paediatric patients with neutropenic sepsis.

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Lorenz GrigullHans-Gert Heuft

Abstract

In this retrospective, uncontrolled, observational study, the effect of granulocyte colony-stimulating factor (G-CSF)-stimulated granulocyte transfusions (GTX) in neutropenic paediatric patients with sepsis was evaluated. Granulocytes were collected from unrelated, ABO group-matched and cytomegalic-antibody compatible donors. For neutrophil mobilization, donors received a single subcutaneous dose of glycosylated G-CSF (Lenograstim, Chugai Pharma, Japan) plus oral dexamethasone (8 mg). In total, 168 (range 1-19 per patient) GTX were transfused in 32 children with a median age of 7.4 (0.25 to 16) years. The underlying diseases comprised predominantly haematooncological malignancies (31 children). In 15 of 32 patients, neutropenia was related to allogeneic stem cell transplantation. All children suffered from sepsis based on international criteria (fever, tachycardia, respiratory rate >2 SD above normal in the context of a suspected or proven infection). In ten children bacteria were isolated, in six children a fungal infection was diagnosed and four sepsis episodes were caused by viral infections. GTX contained a median neutrophil number of 6.3 (range 1.9-13.9)x10(10) per transfusion and obtained a sustained haematological respon...Continue Reading

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Citations

Oct 13, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Simone Cesaro, Piero Marson
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Methods Mentioned

BETA
biopsy
bronchoalveolar lavage

Software Mentioned

SPSS
Spectra

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