PMID: 9546580Apr 18, 1998Paper

G-CSF receptor-mediated up-regulation of c-fos but not c-raf mRNA expression in myeloid cells

Molecular and Cellular Biochemistry
R V Deshpande, M A Moore

Abstract

Granulocyte colony stimulating factor (G-CSF) regulates survival, proliferation, and differentiation of myeloid precursor cells. One of the signaling mechanisms for the G-CSF receptor (G-CSF-R) involves the activation of Ras/MAP kinase (MEK) pathway. Since Raf is an important, common link between Ras and MEK in the Ras-Raf-MEK cascade, we studied the expression of c-raf mRNA in G-CSF-treated myeloid precursor cell lines--NFS-60 and HL-60. G-CSF did not alter c-raf mRNA expression in these cells up to 24 h, but induced a transient up-regulation of c-fos mRNA expression between 15-60 min post-treatment. Our results show that G-CSF triggers a de novo induction of c-fos but not c-raf mRNA, and suggests that G-CSF-R-mediated activation of Ras/MEK pathway may involve post-transcriptional mechanisms of Raf regulation.

Citations

Apr 6, 2016·The Journal of Biological Chemistry·Arathy S KumarSuresh K Rayala

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