PMID: 490582Aug 1, 1979Paper

G gamma beta + type of hereditary persistence of fetal haemoglobin in association with Hb C

Journal of Medical Genetics
D R HiggsD J Weatherall

Abstract

This report describes a Negro family with the G gamma beta + type of hereditary persistence of fetal haemoglobin. Family members with levels of haemoglobin F of 17 to 23% had normal red cell indices, balanced globin chain synthesis, and a pancellular distribution of the fetal haemoglobin, showing that these subjects have a form of HPFH. The production of Hb A and C in addition to the large amount of Hb F in one family member showed that there was an active beta A gene in cis to the HPFH determinant, while structural analysis of the Hb F revealed the presence of only G gamma chains. The criteria for the diagnosis of G gamma beta + HPFH, and the relevance of such conditions to the control of globin gene expression, are discussed.

References

Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J G MearsA Bank
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Citations

Nov 1, 1980·British Journal of Haematology·D R HiggsD J Weatherall
Jan 1, 1981·British Journal of Haematology·D R HiggsD J Weatherall
Jan 10, 2013·Hemoglobin·Cathleen M CookJane S Hankins
Dec 1, 1979·British Journal of Haematology·W G WoodD J Weatherall
Jun 1, 1987·Postgraduate Medicine·A W MartinM Martinez
Aug 1, 1987·American Journal of Hematology·H J HuangT H Huisman
Mar 1, 1979·Cell·D J Weatherall, J B Clegg

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