PMID: 13563759Aug 1, 1958Paper

G Gamma globulins in germ-free rats

The Journal of Experimental Medicine
B E Gustafsson, C B LAURELL

Abstract

The electrophoretic fractions of serum proteins were studied up to the 5th generation in a colony of germ-free rats. The germ-free animals had significantly lower concentrations of beta and the gamma globulins, while the other fractions were within normal limits. Assuming that the gamma globulins survive equally long in the circulation in germ-free animals as in controls, the production of gamma globulins in normal rats is three times as rapid as in germ-free rats. This suggests that the normal flora of microorganisms is an important stimulant for the gamma globulin-producing cells.

References

Nov 1, 1957·The Journal of Infectious Diseases·G J THORBECKEJ A REYNIERS

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Citations

Jan 1, 1979·Folia Microbiologica·J Sterzl
Nov 1, 1983·Molecular Immunology·D M SegalJ A Titus
Jun 5, 1965·Nature·B S WostmannJ R Pleasants
Jan 1, 1959·The New England Journal of Medicine·D GITLINC A JANEWAY
Sep 15, 1966·The New England Journal of Medicine·C A AlperC A Janeway
Nov 1, 1959·The Journal of Experimental Medicine·B E GUSTAFSSON, C B LAURELL
May 1, 1973·Japanese Journal of Microbiology·Y Morishita, T Mitsuoka
Jul 1, 1960·Oral Surgery, Oral Medicine, and Oral Pathology·R J FITZGERALDH R STANLEY
Jan 1, 1970·Acta Pathologica Et Microbiologica Scandinavica. Section B: Microbiology and Immunology·T Midtvedt, A Trippestad
Aug 31, 1961·Annals of the New York Academy of Sciences·M WAGNER, B S WOSTMANN
May 8, 1959·Annals of the New York Academy of Sciences·B E GUSTAFSSON
Aug 31, 1961·Annals of the New York Academy of Sciences·B S WOSTMANN
Dec 1, 1971·Bacteriological Reviews·H A Gordon, L Pesti
Sep 1, 1959·Clinica Chimica Acta; International Journal of Clinical Chemistry·H E SCHULTZE
Nov 23, 2006·Seminars in Immunology·Karen SmithAndrew J Macpherson
Jun 28, 1963·Science·L P WHITE, E F CLAFLIN

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