G-protein α-subunit (GPA1) regulates stress, nitrate and phosphate response, flavonoid biosynthesis, fruit/seed development and substantially shares GCR1 regulation in A. thaliana

Plant Molecular Biology
Navjyoti ChakrabortyNandula Raghuram

Abstract

Heterotrimeric G-proteins are implicated in several plant processes, but the mechanisms of signal-response coupling and the roles of G-protein coupled receptors in general and GCR1 in particular, remain poorly understood. We isolated a knock-out mutant of the Arabidopsis G-protein α subunit (gpa1-5) and analysed its transcriptome to understand the genomewide role of GPA1 and compared it with that of our similar analysis of a GCR1 mutant (Chakraborty et al. 2015, PLoS ONE 10(2):e0117819). We found 394 GPA1-regulated genes spanning 79 biological processes, including biotic and abiotic stresses, development, flavonoid biosynthesis, transcription factors, transporters and nitrate/phosphate responses. Many of them are either unknown or unclaimed explicitly in other published gpa1 mutant transcriptome analyses. A comparison of all known GPA1-regulated genes (including the above 394) with 350 GCR1-regulated genes revealed 114 common genes. This can be best explained by GCR1-GPA1 coupling, or by convergence of their independent signaling pathways. Though the common genes in our GPA1 and GCR1 mutant datasets constitute only 26% of the GPA1-regulated and 30% of the GCR1-responsive genes, they belong to nearly half of all the processes af...Continue Reading

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Citations

Dec 5, 2015·Frontiers in Plant Science·Navjyoti ChakrabortyNandula Raghuram
Apr 21, 2016·Plant Science : an International Journal of Experimental Plant Biology·Alessandra RogatoMaurizio Chiurazzi
Aug 16, 2016·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Quan XuQian Liu
Jan 14, 2020·Journal of Experimental Botany·Sona Pandey
Jun 20, 2017·Frontiers in Plant Science·Sihui ZhongKosala Ranathunge
Oct 9, 2018·Frontiers in Plant Science·Ting-Ying Wu, Daisuke Urano
Apr 11, 2019·Scientific Reports·Navjyoti ChakrabortyNandula Raghuram
Dec 29, 2020·Frontiers in Plant Science·Hongmei FanYong Wang

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