G protein abnormalities in pituitary adenomas

Molecular and Cellular Endocrinology
A SpadaE Ballaré

Abstract

It has been demonstrated that the majority of secreting and nonsecreting adenomas is monoclonal in origin suggesting that these neoplasia arise from the replication of a single mutated cell, in which growth advantage results from either activation of protooncogenes or inactivation of antioncogenes. Although a large number of genes has been screened for mutations, only few genetic abnormalities have been found in pituitary tumors such as allelic deletion of chromosome 11q13 where the MEN-1 gene has been localised, and mutations in the gene encoding the alpha subunit of the stimulatory Gs and Gi2 protein. These mutations constitutively activate the alpha subunit of the Gs and Gi2 protein by inhibiting their intrinsic GTPase activity. Both Gs alpha and Gi2alpha can be considered products of protooncogenes (gsp and gip2, respectively) since gain of function mutations that activate mitogenic signals have been recognized in human tumors. Gsp oncogene is found in 30-40% of GH-secreting adenomas, in a low percentage of nonfunctioning and ACTH-secreting pituitary adenomas, in toxic thyroid adenomas and differentiated thyroid carcinomas. The same mutations, occurred early in embriogenesis, have been also identified in tissues from patien...Continue Reading

References

Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·W F SchwindingerM A Levine
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A M PaceH R Bourne
Aug 1, 1991·Endocrine Reviews·M ContiJ V Swinnen
May 1, 1990·Trends in Neurosciences·M R MontminyK K Yamamoto
Jan 1, 1992·Molecular and Cellular Biology·S K GuptaG L Johnson
Dec 1, 1991·Clinical Endocrinology·D F WoodD G Johnston
Jan 1, 1991·Molecular Carcinogenesis·C O'SullivanN R Lemoine
Dec 12, 1991·The New England Journal of Medicine·L S WeinsteinA M Spiegel
Jul 1, 1990·The Journal of Clinical Investigation·J M AlexanderA Klibanski
Dec 1, 1990·The Journal of Clinical Endocrinology and Metabolism·V HermanS Melmed
Aug 10, 1990·Science·J LyonsH R Bourne
Dec 1, 1990·The Journal of Clinical Endocrinology and Metabolism·C A LandisH R Bourne
May 16, 1990·Biochemical and Biophysical Research Communications·I ZacharyH R Bourne
Nov 1, 1990·Journal of Neurosurgery·L B JacobyR L Martuza
Feb 1, 1989·Trends in Biochemical Sciences·J E DumontP P Roger
Feb 1, 1989·Trends in Pharmacological Sciences·L Vallar, J Meldolesi
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·N BillestrupW Vale
Jan 1, 1987·Annual Review of Biochemistry·M Barbacid
Jul 1, 1995·Baillière's Clinical Endocrinology and Metabolism·A Shenker
Jun 1, 1995·Endocrine Reviews·N DhanasekaranG L Johnson
Nov 12, 1993·Science·S J Cook, F McCormick
Feb 1, 1995·European Journal of Clinical Investigation·E A WilliamsonP E Harris
Oct 1, 1994·Journal of Medical Genetics·L C Wilson, R C Trembath
Dec 1, 1994·Clinical Endocrinology·E A WilliamsonP E Harris
Jan 1, 1994·European Journal of Endocrinology·A SpadaG Faglia
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·F M MichielsJ Feunteun
Jun 15, 1994·Biochemical and Biophysical Research Communications·N XuJ S Gutkind
Feb 1, 1994·Current Opinion in Genetics & Development·C J Marshall

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Citations

Mar 29, 2001·The Journal of Pathology·N SeemannW Paulus
Nov 15, 2002·Molecular and Cellular Endocrinology·Anna Spada, Andrea Lania
Mar 20, 2001·The Journal of Clinical Investigation·B E HaywardD T Bonthron
Mar 4, 2000·Journal of Neurosurgery·J C WatsonE H Oldfield
Aug 2, 2002·Journal of Endocrinological Investigation·T C A VieiraJ Abucham
Apr 20, 2006·The International Journal of Biochemistry & Cell Biology·Chung-Man YeungChristopher H K Cheng
Jan 10, 2014·Expert Opinion on Emerging Drugs·Sylvère Störmann, Jochen Schopohl
Jan 18, 2002·Endocrinology·Anna Spada, Paolo Beck-Peccoz
Apr 18, 2008·Expert Review of Neurotherapeutics·Margaret F Keil, Constantine A Stratakis
Jan 31, 2006·Arquivos brasileiros de endocrinologia e metabologia·Milena Gurgel Teles BezerraMaria Candida B V Fragoso
Jun 23, 2006·Journal of Pediatric Endocrinology & Metabolism : JPEM·Luisa de SanctisCarlo de Sanctis
Apr 15, 2008·Cellular Signalling·Martine Müller KlosterHeidi Kiil Blomhoff

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