G-Protein-Coupled Chemokine Receptor Gene in Lumpy Skin Disease Virus Isolates from Cattle and Water Buffalo (Bubalus bubalis) in Egypt

Transboundary and Emerging Diseases
M S El-Tholoth, A A El-Kenawy

Abstract

Lumpy skin disease virus (LSDV), sheep poxvirus (SPV) and goat poxvirus (GPV) are the most serious poxviruses of ruminants. In this study, we analysed the G-protein-coupled chemokine receptor (GPCR) genes of LSDV isolates from cattle and water buffalo (Bubalus bubalis) in Egypt during the summer of 2011. Multiple alignments of the nucleotide sequences revealed that the water buffalo LSDV isolate differed from the cattle isolate at four nucleotide positions, and both isolates had nine nucleotide mutations from the reference strain, Egyptian tissue culture-adapted cattle LSDV/Ismailyia88 strain. Compared with the GPCR sequences of SPV and GPV strains, a 21 nucleotide insertion and a 12 nucleotide deletion were identified in the GPCR genes of our used isolates and other LSDVs. The amino acid sequences of GPCR genes of our isolates contained the unique signature of LSDV (A11 , T12 , T34 , S99 and P199 ). Phylogenetic analyses showed that the GPCR genes of cattle and water buffalo LSDVs were closest genetically, indicating a potential transmission of cattle LSDV to water buffalo.

References

Nov 1, 1991·The British Veterinary Journal·F G Davies
Apr 1, 1990·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·J A HouseN N Ayoub
Oct 1, 1993·Vaccine·V M Carn
Oct 8, 1998·Journal of Virological Methods·D C Ireland, Y S Binepal
Apr 12, 2000·International Journal of Systematic and Evolutionary Microbiology·G CardinaliA Martini
Jul 4, 2001·Journal of Virology·E R TulmanD L Rock
May 22, 2002·Journal of Virology·E R TulmanD L Rock
Jun 25, 2004·Virus Genes·Madhusudan HosamaniThaha Jamal Rasool
Dec 25, 2004·Neuropharmacology·Mette M Rosenkilde
Feb 17, 2005·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Mario GomezY Lynn Wang
Sep 3, 2005·The Onderstepoort Journal of Veterinary Research·E S M TuppurainenJ A W Coetzer
Sep 9, 2008·Transboundary and Emerging Diseases·S BabiukR P Kitching
Nov 3, 2009·Tropical Animal Health and Production·Walid S AwadMervet I Abdel Moniem
Jan 12, 2011·Virologica Sinica·A A El-Kenawy, M S El-Tholoth

❮ Previous
Next ❯

Citations

Nov 4, 2016·BMC Veterinary Research·Mohamed A ShalabyAhmed Abd El Wahed
Feb 23, 2020·BMC Veterinary Research·Sylvester OchwoFrank Norbert Mwiine
Apr 6, 2019·Archives of Virology·Aleksandr KononovAlexander Sprygin
Jun 18, 2020·Frontiers in Veterinary Science·Samuel Kipruto KiplagatNicholas A Lyons
Aug 28, 2020·Veterinary World·Ahmad M AllamTarek Korany Farag
Mar 27, 2021·Comparative Immunology, Microbiology and Infectious Diseases·Elsayyad M AhmedMohamed Fawzy
Aug 31, 2021·Comparative Immunology, Microbiology and Infectious Diseases·Abdelfattah SelimHanem Khater

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.