G protein-coupled estrogen receptor (GPER) mediates NSCLC progression induced by 17β-estradiol (E2) and selective agonist G1

Medical Oncology
Changyu LiuJianmiao Wang

Abstract

Estrogen classically drives lung cancer development via estrogen receptor β (ERβ). However, fulvestrant, an anti-estrogen-based endocrine therapeutic treatment, shows limited effects for non-small cell lung cancer (NSCLC) in phase II clinical trials. G protein-coupled estrogen receptor (GPER), a third estrogen receptor that binds to estrogen, has been found to be activated by fulvestrant, stimulating the progression of breast, endometrial, and ovarian cancers. We here demonstrated that cytoplasm-GPER (cGPER) (80.49 %) and nucleus-GPER (53.05 %) were detected by immunohistochemical analysis in NSCLC samples. cGPER expression was related to stages IIIA-IV, lymph node metastasis, and poorly differentiated NSCLC. Selective agonist G1 and 17β-estradiol (E2) promoted the GPER-mediated proliferation, invasion, and migration of NSCLC cells. Additionally, in vitro administration of E2 and G1 increased the number of tumor nodules, tumor grade, and tumor index in a urethane-induced adenocarcinoma model. Importantly, the pro-tumorigenic effects of GPER induced by E2 were significantly reduced by co-administering the GPER inhibitor G15 and the ERβ inhibitor fulvestrant, as compared to administering fulvestrant alone both in vitro and in viv...Continue Reading

References

Jan 1, 1997·Annual Review of Physiology·M Wehling
Nov 5, 1997·The Journal of Clinical Endocrinology and Metabolism·A W BrandenbergerR B Jaffe
Apr 20, 2004·The Journal of Biological Chemistry·Marcello MaggioliniSebastiano Andò
Feb 12, 2005·Science·Chetana M RevankarEric R Prossnitz
Nov 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Edward J FilardoEdmond Sabo
Dec 25, 2008·Molecular Endocrinology·Guangfeng ZhangHarish Srinivas
May 19, 2009·Technology in Cancer Research & Treatment·G TuT Yu
Jun 9, 2009·Gynecologic Oncology·Harriet O SmithEric R Prossnitz
Aug 12, 2009·Journal of Neuroimmunology·Eric BlaskoRichard Horuk
Feb 18, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher G SlatoreEmily White
Jan 26, 2011·Cancer·Christine BouchardyElisabetta Rapiti
Aug 17, 2011·Nature Reviews. Endocrinology·Eric R Prossnitz, Matthias Barton
Feb 1, 2012·Breast Cancer Research and Treatment·Rainer GirgertCarsten Gründker
Jan 1, 2013·BMC Cancer·Venkatakrishna Rao JalaCarolyn M Klinge
Feb 13, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Edward B GaronDennis J Slamon
May 8, 2013·International Journal of Cancer. Journal International Du Cancer·Hexiao TangSheng Zhou
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Feb 26, 2014·Seminars in Oncology·Jill M Siegfried, Laura P Stabile

❮ Previous
Next ❯

Citations

Aug 8, 2017·International Journal of Molecular Sciences·Li-Han HsuShu-Huei Kao
Feb 14, 2020·Journal of Cellular and Molecular Medicine·Xiaofeng WangXiangdong Cheng
May 11, 2016·Bioscience Reports·Yulia Lipovka, John P Konhilas
Jun 8, 2017·Experimental and Therapeutic Medicine·Donatas StakišaitisAngelija Valančiūtė
Jul 5, 2018·Journal of Experimental & Clinical Cancer Research : CR·Quanfu HuangJing Xiong
Nov 12, 2019·Frontiers in Endocrinology·Shen XuLeo Tsz On Lee
May 6, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·S FanB Ai
Aug 7, 2019·The Journal of Steroid Biochemistry and Molecular Biology·Teeranut AsavasupreecharHironobu Sasano
Feb 13, 2021·Frontiers in Endocrinology·Nicolas ChevalierPatrick Fenichel
Jun 4, 2021·Frontiers in Medicine·Vianey Rodriguez-Lara, Maria Rosa Avila-Costa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.