G protein-coupled receptor 101 mRNA expression in supraoptic and paraventricular nuclei in rat hypothalamus is altered by pregnancy and lactation

Brain Research
K N NilaweeraP Barrett

Abstract

In a previous study performed in mouse models of energetic challenge, there was evidence to suggest that the orphan G protein-coupled receptor GPCR101 may have a role in the regulation of energy balance. To further investigate this possibility, we utilised in situ hybridisation to determine the effect of energetic challenges experienced by pregnant and lactating rats on GPCR101 mRNA expression. In the rat hypothalamus, GPCR101 mRNA expression was detected in a number of hypothalamic nuclei. During pregnancy and lactation, GPCR101 mRNA level remained unchanged in most nuclei, but had increased in the supraoptic nucleus by the end of pregnancy and remained elevated during lactation. GPCR101 mRNA expression showed a similar pattern of expression in the rostral ventromedial parvocellular subdivision of the paraventricular nucleus. A common feature of these two nuclei is the production of the peptide oxytocin. Dual in situ hybridisation revealed GPCR101 and oxytocin mRNA co-expression in neurons of these two nuclei. In the supraoptic nucleus, in situ hybridisation revealed that the temporal regulation of oxytocin and GPCR101 mRNA expression were similar. In the paraventricular nucleus, although temporal changes in oxytocin mRNA expr...Continue Reading

References

Dec 1, 1990·Physiology & Behavior·R ArlettiA Bertolini
Jul 1, 1981·The British Journal of Nutrition·B Morgan, M Winick
Nov 1, 1980·Physiology & Behavior·J H Strubbe, J Gorissen
Jul 11, 1998·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·P S WiddowsonG Williams
Jul 24, 1998·Biochemical and Biophysical Research Communications·L PickavanceR G Vernon
Jan 26, 2002·Microscopy Research and Technique·Takashi Higuchi, Chuma O Okere
Mar 12, 2002·The European Journal of Neuroscience·Kanishka N NilaweeraPeter J Morgan
Jul 20, 2002·Frontiers in Neuroendocrinology·M Susan Smith, Kevin L Grove
Mar 1, 2003·Frontiers in Neuroendocrinology·John A RussellAlison J Douglas
Apr 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Demetrios K VassilatisGeorge A Gaitanaris
May 7, 2005·Domestic Animal Endocrinology·K Svennersten-Sjaunja, K Olsson
Aug 16, 2005·Journal of Chemical Neuroanatomy·Ken W S Ashwell, George Paxinos
Sep 10, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Janet A AmicoLinda Rinaman

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Citations

Jan 27, 2016·Proceedings of the National Academy of Sciences of the United States of America·Ahmed MahfouzOnno C Meijer
Mar 11, 2016·Endocrine-related Cancer·Giampaolo TrivellinConstantine A Stratakis
Jun 11, 2016·Journal of Molecular Endocrinology·Giampaolo TrivellinConstantine A Stratakis
Nov 18, 2015·Current Opinion in Endocrinology, Diabetes, and Obesity·Maya B LodishConstantine A Stratakis
Nov 23, 2017·Frontiers in Endocrinology·Bradly M BaumanT John Wu

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