G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator

Nature
C BaisM C Gerhengorn

Abstract

The Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8) is a gamma-2 herpesvirus that is implicated in the pathogenesis of Kaposi's sarcoma and of primary effusion B-cell lymphomas (PELs). KSHV infects malignant and progenitor cells of Kaposi's sarcoma and PEL, it encodes putative oncogenes and genes that may cause Kaposi's sarcoma pathogenesis by stimulating angiogenesis. The G-protein-coupled receptor encoded by an open reading frame (ORF 74) of KSHV is expressed in Kaposi's sarcoma lesions and in PEL and stimulates signalling pathways linked to cell proliferation in a constitutive (agonist-independent) way. Here we show that signalling by this KSHV G-protein-coupled receptor leads to cell transformation and tumorigenicity, and induces a switch to an angiogenic phenotype mediated by vascular endothelial growth factor, an angiogenesis and Kaposi's-spindle-cell growth factor. We find that this receptor can activate two protein kinases, JNK/SAPK and p38MAPK, by triggering signalling cascades like those induced by inflammatory cytokines that are angiogenesis activators and mitogens for Kaposi's sarcoma cells and B cells. We conclude that the KSHV G-protein-coupled receptor is a viral oncogene that can exploit cell signalling path...Continue Reading

References

Dec 11, 1992·Science·A E KochR M Strieter
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J S GutkindK C Robbins
May 4, 1995·The New England Journal of Medicine·E CesarmanD M Knowles
Feb 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R T PremontR J Lefkowitz
Jan 1, 1995·Breast Cancer Research and Treatment·W KolchD Marmé
Oct 4, 1996·The Journal of Biological Chemistry·J M Kyriakis, J Avruch
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·J J RussoP S Moore
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·R MasoodP S Gill
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N Ferrara
Aug 26, 1998·Advances in Cancer Research·C Boshoff, R A Weiss

❮ Previous
Next ❯

Citations

Aug 21, 2003·Journal of Biomedical Science·John Nicholas
Jul 14, 1999·Cell Biochemistry and Biophysics·I Dikic, A Blaukat
Jul 26, 2003·Folia Microbiologica·J Rajcáni, M Kúdelová
Aug 24, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yarí E Marín, Suzie Chen
Jan 13, 2001·Springer Seminars in Immunopathology·D H McDermott, P M Murphy
Nov 19, 2008·Cell and Tissue Research·Leonid L Nikitenko
Oct 19, 2007·Archives of Virology·N CloutierL Flamand
Aug 11, 2005·Current Oncology Reports·Emily L Wong, Blossom Damania
May 14, 1999·Trends in Pharmacological Sciences·M N Devalaraja, A Richmond
Sep 11, 1999·Trends in Neurosciences·R J Miller, O Meucci
May 22, 1998·Trends in Genetics : TIG·P S Moore, Y Chang
Apr 19, 2002·Biochimica Et Biophysica Acta·Richard G Jenner, Chris Boshoff
Aug 26, 1998·Trends in Microbiology·J P Simas, S Efstathiou
Jun 4, 1999·Trends in Microbiology·T F Schulz, P S Moore
Dec 16, 1998·Trends in Biochemical Sciences·R LeursH Timmerman
Sep 1, 2005·Nature Clinical Practice. Oncology·Robert YarchoanRichard F Little
Sep 25, 2010·Nature Reviews. Cancer·Enrique A MesriChris Boshoff
Jan 5, 2011·Nature Reviews. Drug Discovery·Rosamaria Lappano, Marcello Maggiolini
Dec 2, 2004·Nature Reviews. Molecular Cell Biology·Akrit SodhiJ Silvio Gutkind
Jul 21, 2004·Nature Reviews. Microbiology·Blossom Damania
Aug 26, 2010·Nature Reviews. Nephrology·Inés Rama, Josep M Grinyó
May 17, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Stephanie CherquiDaniel R Salomon
Jul 20, 1999·Kidney International·P M Ronco
Mar 18, 1999·Pathology Oncology Research : POR·G MikalaI Vályi-Nagy
Apr 6, 2000·The New England Journal of Medicine·K Antman, Y Chang
Sep 29, 2006·The New England Journal of Medicine·Robert Yarchoan
May 12, 2009·Proceedings of the National Academy of Sciences of the United States of America·Qi MaPascal J Goldschmidt-Clermont
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tao MaSilvia Montaner
Jun 4, 2008·Sarcoma·R J OlsenS H Hinrichs
Jan 6, 2000·The Journal of Experimental Medicine·H R LüttichauT W Schwartz
Feb 9, 2000·The Journal of Experimental Medicine·E CesarmanM C Gershengorn
Aug 4, 2004·The Journal of Experimental Medicine·Britt Glaunsinger, Don Ganem
May 22, 2008·The Journal of Infectious Diseases·Clyde S Crumpacker

❮ Previous
Next ❯

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