G protein-coupled receptors in cancer stem cells

Current Pharmaceutical Design
Yuhong JiangCanquan Mao

Abstract

G protein-coupled receptors (GPCRs) are highly expressed on a variety of tumour tissues while several GPCR exogenous ligands become marketed pharmaceuticals since they can target GPCRs to modulate plenty of cancer cell functions. In recent decades, cancer stem cells (CSCs) become widely investigated drug targets for cancer therapy but its underlying mechanism is still not fully elucidated. There are vigorous participations of GPCRs in CSCs-related signalling and functions, such as biomarkers for CSCs, essential receptors for activating Wnt, Hedgehog (HH) and other signalling pathways to facilitate CSCs progressions. This relationship can not only uncover a novel molecular mechanism for GPCR-mediated cancer cell functions but also assist our understanding in maintaining and modulating CSCs. Moreover, GPCR antagonists and monoclonal antibodies could be applied to impair CSCs functions and consequently attenuate tumour growth, which are anticipated to turn into marketed anticancer drugs via monotherapy or combination therapy with validated chemicals after clinical studies. Therefore, this review summarizes and provides sufficient evidences on regulation of GPCR signalling in the maintenance, differentiation and pluripotency of CSC...Continue Reading

References

Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·J C HsiehJ Nathans
Sep 28, 2000·Trends in Neurosciences·C Heuss, U Gerber
Mar 10, 2001·Trends in Pharmacological Sciences·N VergnolleM D Hollenberg
Apr 21, 2001·Oncogene·I P WhiteheadC J Der
Jun 5, 2002·Nature Reviews. Cancer·Ariel Ruiz i AltabaNadia Dahmane
Apr 30, 2003·Nature·Tannishtha ReyaIrving L Weissman
Jun 7, 2003·Science·Hsien-Yu Wang, Craig C Malbon
Aug 20, 2003·The Journal of Investigative Dermatology·Glynis ScottRujiing Han
Jan 19, 2007·Nature Reviews. Genetics·Jessica R K Seifert, Marek Mlodzik
Jan 26, 2007·Nature Reviews. Cancer·Robert T Dorsam, J Silvio Gutkind
Jul 20, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Masuko Katoh, Masaru Katoh
Sep 12, 2007·Trends in Cell Biology·Ariel Ruiz i AltabaBarbara Stecca
Oct 3, 2007·Cancer Research·Jeremy N Rich
Feb 15, 2008·Cancer Science·Chikako FukukawaToyomasa Katagiri
Oct 14, 2008·Nature Genetics·Viljar JaksRune Toftgård
Nov 11, 2008·Journal of Endocrinological Investigation·S GelminiE Lazzeri
Nov 22, 2008·Cancer Letters·Zhiwei WangFazlul H Sarkar
Mar 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ingrid U SchraufstatterSophia K Khaldoyanidi
May 22, 2009·Nature·Daniel M RosenbaumBrian K Kobilka
Apr 27, 2010·Nature Cell Biology·Louis VermeulenJan Paul Medema
Jun 10, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Antonio PannutiLucio Miele
Nov 16, 2010·Pharmacology & Therapeutics·Phillip CallihanShelley B Hooks
Dec 15, 2010·Nature Reviews. Clinical Oncology·Naoko TakebeS Percy Ivy
Jan 5, 2011·Nature Reviews. Drug Discovery·Rosamaria Lappano, Marcello Maggiolini
Jan 7, 2011·The Journal of Biological Chemistry·Mercedes BarziSebastian Pons
Mar 10, 2011·Nature Medicine·Hans Clevers
Apr 27, 2011·Clinical and Experimental Medicine·Fei TianAlbrecht Bergner
Jun 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kendra S CarmonQingyun Liu

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Citations

Jun 12, 2020·Current Pharmaceutical Design·Sanjun Shi, Wenliang Li
Jul 17, 2021·Cellular and Molecular Gastroenterology and Hepatology·Barbara Joanna Niklinska-SchirtzSubra Kugathasan

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