G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins.

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins.

Abstract

Citations

Stable expression of a functional rat angiotensin II (AT1A) receptor in CHO-K1 cells: rapid desensitization by angiotensin II

Differential G protein measures in mononuclear leukocytes of patients with bipolar mood disorder are state dependent

Identification and chromosomal localization of a processed pseudogene of human GRK6

Identification of proteins interacting with the rat somatostatin receptor subtype 2

Binding between a distal C-terminus fragment of cannabinoid receptor 1 and arrestin-2

GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.

MEK1 binds directly to betaarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.

Beta adrenoceptor density in patients with left-sided valvular regurgitation

cAMP-mediated signal transduction and sarcoplasmic reticulum function in heart failure

Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.

Parathyroid hormone induces bone formation in phosphorylation-deficient PTHR1 knockin mice.

Gpr3 stimulates Aβ production via interactions with APP and β-arrestin2

Visual Arrestin 1 acts as a modulator for N-ethylmaleimide-sensitive factor in the photoreceptor synapse.

Interaction of a fragment of the cannabinoid CB1 receptor C-terminus with arrestin-2.

Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex

Preterm labour. Biochemical and endocrinological preparation for parturition

Differential functional expression of human myocardial G protein receptor kinases in left ventricular cardiac diseases

Desensitization to gonadotropic hormones: a model system for the regulation of a G-protein-coupled receptor with 7-transmembrane spanning regions

The influence of beta-arrestin2 on cannabinoid CB1 receptor coupling to G-proteins and subcellular localization and relative levels of beta-arrestin1 and 2 in mouse brain

The effects of beta-arrestin1 deletion on acute cannabinoid activity, brain cannabinoid receptors and tolerance to cannabinoids in mice

Contraction inhibition by beta-agonists progressively decreases before labor in the rat myometrium

Expression of beta-adrenergic receptor kinase subtypes in the pregnant rat myometrium

Arrestin binding determines the rate of inactivation of the G protein-coupled receptor rhodopsin in vivo

β-arrestin regulates estradiol membrane-initiated signaling in hypothalamic neurons

Arrestins and two receptor kinases are upregulated in Parkinson's disease with dementia

A functional role for Anopheles gambiae Arrestin1 in olfactory signal transduction.

Toll-like receptors differentially regulate GPCR kinases and arrestins in primary macrophages

Development of a novel DnaE intein-based assay for quantitative analysis of G-protein-coupled receptor internalization

Loss of betaarrestin1 and betaarrestin2 contributes to pulmonary hypoplasia and neonatal lethality in mice

G-protein coupled receptor kinase-like immunoreactivity in the snail, Helix pomatia, neurons

Restoration of myocardial beta-adrenergic receptor signaling after left ventricular assist device support

Trans-generational desensitization and within-generational resensitization of a sucrose-best neuron in the polyphagous herbivore Helicoverpa armigera (Lepidoptera: Noctuidae)

Mammalian sweet taste receptors

Rat somatostatin receptor subtype 4 can be made sensitive to agonist-induced internalization by mutation of a single threonine (residue 331)

Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization.

Polymorphisms present in G-protein-coupled receptor kinases and their effect on β-blocker treatment.

Platelet-activating factor-induced chemokine gene expression requires NF-kappaB activation and Ca2+/calcineurin signaling pathways. Inhibition by receptor phosphorylation and beta-arrestin recruitment

Inhibition of protein kinase C prevents rapid desensitization of type 1B angiotensin II receptor

β-arrestins and biased signaling in gonadotropin receptors

A key role for protein kinase A in homologous desensitization of the beta 2-adrenergic receptor pathway in S49 lymphoma cells.

Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization.

Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1.

Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain.

Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1.

Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production

Regulation of N-formyl peptide receptor signaling and trafficking by individual carboxyl-terminal serine and threonine residues

Activation and regulation of platelet-activating factor receptor: role of G(i) and G(q) in receptor-mediated chemotactic, cytotoxic, and cross-regulatory signals

Chronic delta9-tetrahydrocannabinol treatment produces a time-dependent loss of cannabinoid receptors and cannabinoid receptor-activated G proteins in rat brain.

T2Rs function as bitter taste receptors

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