PMID: 2122451Oct 1, 1990Paper

G protein diversity is increased by associations with a variety of gamma subunits

Proceedings of the National Academy of Sciences of the United States of America
N GautamM I Simon

Abstract

Guanine nucleotide-binding regulatory proteins (G proteins) are heterotrimeric proteins that transduce extracellular signals into intracellular changes. Functionally different G proteins have been identified by their different alpha subunits. The beta and gamma subunits have been assumed to constitute a common pool shared among various G protein heterotrimers. Two gamma subunits (gamma 3 and gamma 4) have been identified through molecular cloning; these are in addition to two subunits (gamma 1 and gamma 2) that were previously characterized. G proteins purified from a variety of mammalian tissues were examined with antisera specific to three of the gamma subunits. The antisera react with different gamma subunits associated with some of the purified G proteins but not all. This demonstrates that different G protein heterotrimers from different tissues carry structurally distinct members of the gamma-subunit family. Diversity in the structure of the gamma as well as the alpha and beta subunits and preferential associations between members of subunit families increase structural and possibly functional diversity of G proteins.

References

Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M A LevineT G Ahn
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H K YamaneJ A Glomset
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S M MumbyP C Sternweis
May 26, 1989·Science·N GautamM I Simon
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M StrathmannM I Simon
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K YatsunamiH G Khorana
Jul 12, 1988·Biochemistry·M A Lochrie, M I Simon
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B K FungL Stryer
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J B HurleyM I Simon
Sep 1, 1983·Cell·E TaparowskyM Wigler
Jan 1, 1981·Annual Review of Biochemistry·S C Hubbard, R J Ivatt

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Citations

Jul 1, 1996·Molecular Reproduction and Development·C J WilliamsG S Kopf
Jan 1, 1991·Pharmacology & Therapeutics·A Levitzki, A Bar-Sinai
Jan 1, 1991·Pharmacology & Therapeutics·J Olate, J E Allende
May 1, 1995·Cellular Signalling·L Paquereau, Y Audigier
Jun 1, 1991·Current Opinion in Neurobiology·J Bockaert
Jan 1, 1992·Trends in Cardiovascular Medicine·E J Neer, D E Clapham
May 1, 1996·Trends in Cardiovascular Medicine·K RayJ D Robishaw
Oct 29, 1996·Biochimica Et Biophysica Acta·E J Helmreich, K P Hofmann
May 30, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G M KellyS Mangos
Oct 1, 1998·Cellular Signalling·N GautamO Kisselev
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M P Strathmann, M I Simon
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·A N Pronin, N Gautam
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J MitchellB P Schimmer
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y W PengK W Yau
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S MüllerM J Lohse
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D E WildmanM Dennis
Mar 15, 1992·European Journal of Biochemistry·H HeithierE J Helmreich
Jun 15, 1992·European Journal of Biochemistry·M CampsP Gierschik
May 10, 1991·Science·M I SimonN Gautam
Aug 18, 2004·Molecular and Cellular Biology·William F SchwindingerJanet D Robishaw
Jan 1, 1992·Drug Metabolism Reviews·S Garattini
Apr 15, 1992·Biochemical and Biophysical Research Communications·H SohmaT Akino
Feb 28, 1992·Biochemical and Biophysical Research Communications·E von WeizsäckerM I Simon
Jun 15, 2005·Neuron·Heather L AglerDavid T Yue
Dec 8, 2005·Molecular & Cellular Proteomics : MCP·Lana A CookJohn D Hildebrandt
Sep 29, 1995·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H R Bourne

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