G-protein-independent activation of Tyk2 by the platelet-activating factor receptor

The Journal of Biological Chemistry
V LukashovaJ Stanková

Abstract

Platelet-activating factor (PAF) is a potent pro-inflammatory phospholipid with multiple physiological and pathological effects. PAF exerts its activity through a specific heptohelical G-protein coupled receptor, expressed on a variety of cell types, including leukocytes. In this study, we showed that PAF induced a rapid tyrosine phosphorylation of the Tyk2 kinase in the monocytic cell lines U937 and MonoMac-1. PAF-initiated Tyk2 phosphorylation was also observed in COS-7 cells transiently transfected with the human PAF receptor (PAFR) and Tyk2 cDNAs. In addition, we found that Tyk2 co-immunoprecipitated and co-localized with PAFR, independently of ligand binding. Deletion mutants of Tyk2 indicated that the N terminus of the kinase was important for the binding to PAFR. Activation of Tyk2 was followed by a time-dependent 2-4-fold increase in the level of tyrosine phosphorylation of signal transducers and activators of transcription 1 (STAT1), STAT2, and STAT3 and a sustained 2.5-fold increase in STAT5 tyrosine phosphorylation. In MonoMac-1 cells, STAT1 and STAT3 translocated to the nucleus following PAF stimulation, and their translocation in transiently transfected COS-7 cells was shown to be dependent on the presence of Tyk2....Continue Reading

References

Jun 23, 1995·The Journal of Biological Chemistry·V V KravchenkoR D Ye
Jun 1, 1994·Trends in Pharmacological Sciences·L OliveiraG Vriend
Jun 15, 1993·The Biochemical Journal·W Chao, M S Olson
Dec 7, 1995·Biochimica Et Biophysica Acta·T Izumi, T Shimizu
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·H MutohS Kato
Aug 1, 1997·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·P DagenaisM Rola-Pleszczynski
Nov 5, 1997·Biochemical and Biophysical Research Communications·K RezaulH Yamamura
Feb 7, 1998·The Journal of Biological Chemistry·M Wong, E N Fish
Mar 28, 1998·The Journal of Biological Chemistry·H YanJ J Krolewski
May 23, 1998·Annual Review of Immunology·W J Leonard, J J O'Shea
Jun 25, 1998·Current Opinion in Immunology·K D LiuM A Goldsmith
Feb 13, 1999·The Journal of Biological Chemistry·J HerringtonC Carter-Su
Feb 26, 1999·The Journal of Cell Biology·J M Rodríguez-FradeM Mellado
Apr 23, 1999·The Journal of Biological Chemistry·C Le GouillJ Stanková
Sep 28, 2000·Trends in Neurosciences·C Heuss, U Gerber

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Nov 26, 2009·Nature Reviews. Molecular Cell Biology·Stefanie L Ritter, Randy A Hall
Nov 15, 2007·Molecular BioSystems·Yutong SunXin-Yun Huang
May 23, 2002·DNA and Cell Biology·Stéphane Veilleux, Guylain Boissonneault
Jan 31, 2003·Molecular and Cellular Biology·Stéphane PelletierSylvain Meloche
Oct 7, 2008·Annual Review of Pharmacology and Toxicology·Denis J DupréTerence E Hébert
Aug 9, 2005·Seminars in Pediatric Surgery·Michael S CaplanTamas Jilling
Apr 29, 2005·Journal of Neurochemistry·Georgia Mazarakou, Zafiroula Georgoussi
Jan 25, 2012·Journal of Receptor and Signal Transduction Research·Ting ShiDianne M Perez
Jun 26, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Maud A W HermansWillem A Dik
Dec 24, 2004·The Journal of Biological Chemistry·Barbara AhrMartine Biard-Piechaczyk
Jan 28, 2005·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Denis J DupréJana Stanková
Jan 28, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ling ChengKaren M Harnett
Aug 27, 2013·Molecular and Cellular Biochemistry·Astrid J FeuerhermBerit Johansen
Jun 29, 2017·Pharmacological Reviews·Anna CooperAndrea J Vernall
Mar 26, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hélène Hudry-ClergeonIsabelle Vilgrain
Sep 23, 2003·The Journal of Biological Chemistry·Denis J DupréJana Stankova
Mar 30, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cristina CellaiFrancesco Paoletti
Sep 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Viktoria LukashovaJana Stanková
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Seung Hyun HanMoon H Nahm
Jul 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Caroline PoissonMarek Rola-Pleszczynski
Aug 16, 2018·Frontiers in Oncology·Emira Bousoik, Hamidreza Montazeri Aliabadi
Mar 6, 2019·Cell Communication and Signaling : CCS·Geneviève Hamel-CôtéJana Stankova
Jan 8, 2004·Critical Reviews in Clinical Laboratory Sciences·Diana M StafforiniStephen M Prescott
May 9, 2006·Cellular Signalling·Denis J Dupré, Terence E Hébert

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