Abstract
Most olfactory receptors in vertebrates are G protein-coupled receptors, whose activation by odorants initiates intracellular signaling cascades through heterotrimeric G proteins consisting of α, β, and γ subunits. Abolishment of the α subunits such as Gαolf in the main olfactory epithelium and Gαi2 and Gαo in the vomeronasal organ resulted in anosmia and/or impaired behavioral responses. In this study, we report that a G protein γ subunit, Gγ13, is expressed in a spatiotemporal manner similar to those of Gαolf and Gαi2 in the olfactory system and vomeronasal organ, respectively. In addition, Gγ13 was found in the glomeruli of the main olfactory bulb but was largely absent in the glomeruli of the accessory olfactory bulb. Using the Cre-loxP system, the Gγ13's gene Gng13 was nullified in the mature olfactory sensory neurons and apical vomeronasal sensory neurons where the Cre recombinase was expressed under the promoter of the Omp gene for the olfactory marker protein. Immunohistochemistry indicated much reduced expression of Gγ13 in the apical vomeronasal epithelium of the mutant mice. Behavioral experiments showed that the frequency and duration of aggressive encounters in the male mutant mice were significantly lower than in ...Continue Reading
References
Nov 26, 1999·Nature Neuroscience·L HuangR F Margolskee
Feb 2, 2002·Science·Lisa StowersGeorgy Koentges
Jul 18, 2003·Current Biology : CB·E Marianne NorlinAnna Berghard
Dec 4, 2003·Neuron·Philippe LucasFrank Zufall
Mar 26, 2004·Nature·Jinsong LiPeter Mombaerts
Aug 24, 2004·Nature Genetics·Heather M KulagaNicholas Katsanis
Sep 27, 2005·Physiological Reviews·Nina Wettschureck, Stefan Offermanns
Oct 12, 2005·Journal of Neurocytology·Tomohiro IshiiPeter Mombaerts
Nov 17, 2006·Nature·Peter A Brennan, Frank Zufall
May 9, 2008·Molecular and Cellular Neurosciences·Daniel S KerrBettina Malnic
Sep 24, 2008·Annual Review of Physiology·Steven D MungerFrank Zufall
Jul 7, 2009·Annual Review of Physiology·Kazushige Touhara, Leslie B Vosshall
Jul 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Pablo ChameroTrese Leinders-Zufall
Jun 5, 2012·Trends in Neurosciences·Pablo ChameroFrank Zufall
Jul 31, 2012·Nature Neuroscience·SangSeong KimC Ron Yu
May 3, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Feng LiLiquan Huang
Jun 14, 2013·Frontiers in Cellular Neuroscience·Aaron SathyanesanWeihong Lin
Jul 10, 2013·The Journal of Physiology·Giorgia MontaniRoberto Tirindelli
Aug 31, 2013·Annual Review of Physiology·Stephen D Liberles
Apr 12, 2014·Science·Limei MaC Ron Yu
Sep 15, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jung-Mi ChoiHaeyoung Suh-Kim
Aug 18, 2017·Scientific Reports·Stefan KurtenbachManfred W Kilimann
Nov 10, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cleiton F MachadoBettina Malnic
May 18, 2018·The Journal of Biological Chemistry·Jonas MünchThomas J Jentsch
Citations
Feb 26, 2019·Proceedings of the National Academy of Sciences of the United States of America·Anne-Charlotte TrouilletPablo Chamero
Oct 6, 2020·Frontiers in Physiology·Qiu-Yue LinHui-Hua Li
Oct 16, 2020·Journal of Molecular Neuroscience : MN·Cristina SanfilippoMichelino Di Rosa