G protein γ subunit Gγ13 is essential for olfactory function and aggressive behavior in mice

Neuroreport
Qun LiuLiquan Huang

Abstract

Most olfactory receptors in vertebrates are G protein-coupled receptors, whose activation by odorants initiates intracellular signaling cascades through heterotrimeric G proteins consisting of α, β, and γ subunits. Abolishment of the α subunits such as Gαolf in the main olfactory epithelium and Gαi2 and Gαo in the vomeronasal organ resulted in anosmia and/or impaired behavioral responses. In this study, we report that a G protein γ subunit, Gγ13, is expressed in a spatiotemporal manner similar to those of Gαolf and Gαi2 in the olfactory system and vomeronasal organ, respectively. In addition, Gγ13 was found in the glomeruli of the main olfactory bulb but was largely absent in the glomeruli of the accessory olfactory bulb. Using the Cre-loxP system, the Gγ13's gene Gng13 was nullified in the mature olfactory sensory neurons and apical vomeronasal sensory neurons where the Cre recombinase was expressed under the promoter of the Omp gene for the olfactory marker protein. Immunohistochemistry indicated much reduced expression of Gγ13 in the apical vomeronasal epithelium of the mutant mice. Behavioral experiments showed that the frequency and duration of aggressive encounters in the male mutant mice were significantly lower than in ...Continue Reading

References

Jul 18, 2003·Current Biology : CB·E Marianne NorlinAnna Berghard
Sep 27, 2005·Physiological Reviews·Nina Wettschureck, Stefan Offermanns
Nov 17, 2006·Nature·Peter A Brennan, Frank Zufall
Sep 24, 2008·Annual Review of Physiology·Steven D MungerFrank Zufall
Jul 7, 2009·Annual Review of Physiology·Kazushige Touhara, Leslie B Vosshall
Jul 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Pablo ChameroTrese Leinders-Zufall
Jun 5, 2012·Trends in Neurosciences·Pablo ChameroFrank Zufall
May 3, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Feng LiLiquan Huang
Jun 14, 2013·Frontiers in Cellular Neuroscience·Aaron SathyanesanWeihong Lin
Aug 31, 2013·Annual Review of Physiology·Stephen D Liberles
Sep 15, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jung-Mi ChoiHaeyoung Suh-Kim
Nov 10, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cleiton F MachadoBettina Malnic

❮ Previous
Next ❯

Citations

Feb 26, 2019·Proceedings of the National Academy of Sciences of the United States of America·Anne-Charlotte TrouilletPablo Chamero
Oct 16, 2020·Journal of Molecular Neuroscience : MN·Cristina SanfilippoMichelino Di Rosa

❮ Previous
Next ❯

Software Mentioned

PASW Statistics

Related Concepts

Related Feeds

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Feng LiLiquan Huang
Proceedings of the National Academy of Sciences of the United States of America
Pablo ChameroTrese Leinders-Zufall
Proceedings of the National Academy of Sciences of the United States of America
Jung-Mi ChoiHaeyoung Suh-Kim
© 2022 Meta ULC. All rights reserved