G-proteins are involved in contractile responses of isolated mesenteric resistance arteries to agonists

Naunyn-Schmiedeberg's Archives of Pharmacology
H C Boonen, J G De Mey

Abstract

We evaluated whether GTP-binding regulatory proteins (G-proteins) are involved in responses of resistance arterial smooth muscle to contractile agonists. We therefore pretreated isolated sympathectomized mesenteric resistance arteries of the rat with pertussis toxin (PTX) and recorded their contractile responses to aluminium fluoride, endothelin, high potassium, phenylephrine, phorbol myristate acetate, serotonin and vasopressin. PTX reduced contractile responses to agonists with the following order of potency: phenylephrine = serotonin greater than vasopressin = endothelin. The toxin reduced responses to phenylephrine in both the presence and absence of extracellular Ca2+. In Ca2(+)-depleted vessels that were exposed to phenylephrine, PTX virtually abolished responses to Ca2+ while hardly affecting responses to Ca2+ in the presence of endothelin. Also aluminium fluoride and phorbol myristate acetate induced contractions. These were dependent on extracellular Ca2+ and inhibited by felodipine. PTX reduced responses to aluminium fluoride but not those to phorbol myristate acetate. These data indicate that PTX sensitive G-proteins are involved in both influx of Ca2+ and release of intracellular Ca2+ following alpha 1-adrenergic an...Continue Reading

Citations

Jan 1, 1994·Urological Research·P DrescherP O Madsen
Jan 1, 1995·General Pharmacology·W AbebeD K Agrawal
Jun 1, 1993·Current Opinion in Neurobiology·J Hescheler, G Schultz
Mar 27, 2004·European Journal of Pharmacology·Cornelia E van MeijerenDick J de Wildt
Apr 13, 2001·Biochemical Pharmacology·M A PetitcolinE Tschirhart
May 1, 1996·British Journal of Pharmacology·L P WeberK M MacLeod
Oct 1, 1996·British Journal of Pharmacology·P H EerdmansJ G De Mey
Jul 11, 2003·The Journal of Physiology·Philippe GhisdalNicole Morel
Jun 11, 2004·European Journal of Pharmacology·Cornelia E van MeijerenDick J de Wildt

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