G-proteins (Gi, Go) in the basal ganglia of control and schizophrenic brain

Journal of Neural Transmission. General Section
F OkadaG W Roberts

Abstract

We detected the existence of Gi (the inhibitory G-protein) or Go (a similar G-protein of unknown function) in the striatum of control and schizophrenic brains utilizing pertussis toxin-catalyzed ADP ribosylation. The level of Gi/Go was significantly decreased by 42% in the putamen of the left hemisphere in schizophrenics; caudate head and globus pallidus levels were unchanged. Decreased Gi or Go may underlie enhanced dopamine function in the schizophrenic brain.

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Citations

Jan 1, 1994·Journal of Neural Transmission. General Section·F OkadaG W Roberts
Jan 1, 1994·European Archives of Psychiatry and Clinical Neuroscience·F OkadaM Tamura
Oct 20, 1998·Biological Psychiatry·H ShimonG Agam
Nov 1, 1991·Pharmacology & Toxicology·Y OdagakiI Yamashita
Feb 13, 2009·Neuro-Signals·Meisheng Jiang, Neil S Bajpayee
Jul 25, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Philip Seeman
Feb 8, 2008·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·L Xie, G R Arce
Jun 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Valentina K TodorovaSvetlana V Kyosseva
Apr 1, 1993·Reviews in the Neurosciences·N NishinoC Tanaka
Jun 1, 1991·The Japanese Journal of Psychiatry and Neurology·H IwasaT Sato
Jan 1, 1992·Journal of Molecular Neuroscience : MN·S K Gupta, R K Mishra
Dec 19, 2012·Learning & Memory·Jeehaeh DoBong-Kiun Kaang

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