G-Quadruplex surveillance in BCL-2 gene: a promising therapeutic intervention in cancer treatment

Drug Discovery Today
Pallabi SenguptaSubhrangsu Chatterjee

Abstract

Recently, therapeutic implications of BCL-2 quadruplex invigorated the field of clinical oncology. This Keynote review discusses how a BCL-2 quadruplex-selective approach circumvents the limitations of existing therapeutics; and which improvisations might ameliorate the recent trends of quadruplex-based treatment.

Citations

Nov 23, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dawei LiBei Lv
May 21, 2020·Nucleic Acids Research·Julien MarquevielleGilmar F Salgado
Apr 18, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dora M RăsădeanG Dan Pantoș
Dec 29, 2020·Chembiochem : a European Journal of Chemical Biology·Pallabi SenguptaSubhrangsu Chatterjee
Feb 28, 2021·Nucleic Acids Research·Stasė BielskutėPeter Podbevšek

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