G6PD as a predictive marker for glioma risk, prognosis and chemosensitivity

Journal of Neuro-oncology
Chin-An YangJan-Gowth Chang

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme preventing cells from oxidative damage and has been reported to have tumor-promoting roles. This study aims to comprehensively evaluate the predictive values of G6PD on brain tumor risk, prognosis and chemo-resistance. A retrospective 13-year cohort study analyzing cancer risk using the Taiwan National Health Insurance Research Database (4066 G6PD deficiency patients and 16,264 controls) was conducted. Furthermore, RNAseq and clinical data of grade II-III glioma (LGG, n = 515) and glioblastoma (GBM, n = 155) were downloaded from The Cancer Genome Atlas (TCGA) and analyzed. Bioinformatics methods were applied to build a glioma prognostication model and to predict response to chemotherapy based on tumor G6PD-related gene expressions. The predicted results were validated in another glioma cohort GSE 16011 and in KALS1 cell line. G6PD-dificient patients were found to have an increased risk for cancers, especially for brain tumor (adjusted hazard ratio (HR) 10.5, 95% CI 1.03-7.60). Furthermore, higher tumor G6PD expression was associated with poor patient survival in LGG, but not in GBM. A prognostication model using expression levels of G6PD and 9 related genes (PSMA2, PSMB8,...Continue Reading

References

Mar 23, 2002·Free Radical Biology & Medicine·Klaus FelixSiegfried Janz
Jul 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aparna Mani, Edward P Gelmann
Apr 28, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebeca MejíasJosé López-Barneo
Jun 24, 2006·The Oncologist·Jeanine T Grier, Tracy Batchelor
Apr 14, 2009·Journal of Neurosurgery·Kaisorn L ChaichanaAlfredo Quiñones-Hinojosa
Mar 21, 2012·IUBMB Life·Robert C Stanton
Mar 28, 2013·Current Neurology and Neuroscience Reports·Adam L CohenHoward Colman
Sep 27, 2013·Anti-cancer Agents in Medicinal Chemistry·Chunhua ZhangSuofu Qin
May 2, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R StuppUNKNOWN ESMO Guidelines Working Group
Jul 13, 2014·Protein & Cell·Peng JiangMian Wu
Aug 20, 2015·Journal of Neuro-oncology·Yazmín OdiaHoward A Fine
Feb 9, 2016·International Journal of Radiation Oncology, Biology, Physics·Michelle M KimChristina I Tsien
Mar 25, 2016·Science Translational Medicine·Zhen YangCornelia M Weyand
May 7, 2016·Cell Death & Disease·F AhmadE Sen
Jun 21, 2016·Oncotarget·Muhammad ShahidSung Soo Kim
Jun 25, 2016·International Journal of Molecular Sciences·Mariagrazia RinaldiGerardo Caruso
Jul 12, 2016·Cell·Francesco IorioMathew J Garnett
Nov 5, 2016·Free Radical Biology & Medicine·Aaron Wilson, Vasily A Yakovlev
Jul 27, 2017·Frontiers in Cell and Developmental Biology·Rui BenfeitasAdil Mardinoglu
Jul 28, 2017·Journal of Neuro-oncology·Sophie E M Veldhuijzen van ZantenGertjan J L Kaspers
Oct 7, 2017·Seminars in Immunology·Ju ChenKepeng Wang
Nov 25, 2017·Journal of Experimental & Clinical Cancer Research : CR·Xin YinZheng-Gang Ren

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Citations

Sep 11, 2019·Cells·Hung-Chi YangDaniel Tsun-Yee Chiu
Dec 11, 2019·Cells·Cedric MagawayEstela Jacinto
Dec 22, 2020·Biochimica Et Biophysica Acta. General Subjects·Edson Jiovany Ramírez-NavaSaúl Gómez-Manzo
Oct 25, 2020·Biomedical Journal·Hung-Chi YangDaniel Tsun-Yee Chiu

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